Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity

Martin Rowe; Jianmin Zuo

doi:10.1016/j.micinf.2009.12.001

Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity

Martin Rowe
, Jianmin Zuo

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus–host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein–Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation

Original language	English
Pages (from-to)	173-181
Number of pages	9
Journal	Microbes and Infection
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.micinf.2009.12.001
Publication status	Published - 1 Mar 2010

Keywords

Immune-evasion
Tumour virus
Epstein-Barr virus
Herpesvirus
Immune response
Antigen presentation

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10.1016/j.micinf.2009.12.001Licence: Creative Commons: Attribution (CC BY)

http://dx.doi.org/10.1016/j.micinf.2009.12.001Licence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity",

abstract = "Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus–host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein–Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation",

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N2 - Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus–host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein–Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation

AB - Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus–host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein–Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation

KW - Immune-evasion

KW - Tumour virus

KW - Epstein-Barr virus

KW - Herpesvirus

KW - Immune response

KW - Antigen presentation

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DO - 10.1016/j.micinf.2009.12.001

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Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity

Abstract

Keywords

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