Immune evasion strategies of the human gamma-herpesviruses: Implications for viral tumorigenesis

X Zhang, Christopher Dawson, Z He, P Huang

Research output: Contribution to journalArticle

8 Citations (Scopus)


Two human gamma-herpesviruses, Epstein-Barr virus and Kaposi's sarcoma associated herpesvirus/human herpesvirus 8 display oncogenic potential, causing benign and malignant lymphoproliferative disorders in genetically susceptible or immunosuppressed individuals. As a family of viruses that establish persistent life-long infections, herpesviruses have evolved strategies to limit innate antiviral responses and evade host immune surveillance. Herpesviruses have developed mechanisms to disrupt antigen presentation, pirate the production of immune regulating cytokines, and inhibit pro-apoptotic signaling pathways. Although these strategies are designed to facilitate the long-term persistence of herpesviruses, in certain circumstances they can contribute to viral-driven carcinogenesis. J. Med. Virol. 84:272-281, 2012. (C) 2011 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalJournal of Medical Virology
Issue number2
Publication statusPublished - 1 Feb 2012


  • immune escape
  • Kaposi's sarcoma
  • antitumor immunity
  • nasopharyngeal carcinoma
  • mutation
  • antiviral immunity


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