Imaging cerebral blood flow for brain health measurement

Claire Burley; Karen Mullinger; Kate N Thomas; Catarina Rendeiro; Hamid Dehghani; Sam Lucas

doi:10.1016/B978-0-12-819641-0.00157-2

Imaging cerebral blood flow for brain health measurement

Claire Burley, Karen Mullinger, Kate N Thomas, Catarina Rendeiro, Hamid Dehghani, Sam Lucas

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

Cerebral blood flow (CBF) measures are used in clinical settings to diagnose conditions (e.g., vasospasms, sickle cell disease, stroke, dementia, confirmation of brain death), as well as in research, emerging as potential early biomarkers of declining brain health. The aim of this chapter is to provide an overview of approaches used to measure CBF for determining resting cerebral tissue perfusion and functional CBF responsiveness. We will highlight the strengths and weaknesses of each and illustrate the methodological differences that need to be considered when assessing brain vascular health. The imaging methods measuring CBF will cover: Doppler ultrasound (spanning transcranial Doppler (TCD), duplex ultrasound, and transcranial color Doppler (TCCD)), magnetic resonance imaging (MRI) (including arterial spin labeling (ASL), blood oxygenation level dependent (BOLD) signal measures and phase-contrast angiography), and finally near-infrared spectroscopy (NIRS).

Original language	English
Title of host publication	Reference Module in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier
Pages	1-10
Number of pages	10
ISBN (Print)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-819641-0.00157-2
Publication status	Published - 18 Jun 2021

Keywords

Cerebral blood flow
Transcranial Doppler
Duplex ultrasound
Magnetic resonance imaging
Near-infrared spectroscopy

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title = "Imaging cerebral blood flow for brain health measurement",

abstract = "Cerebral blood flow (CBF) measures are used in clinical settings to diagnose conditions (e.g., vasospasms, sickle cell disease, stroke, dementia, confirmation of brain death), as well as in research, emerging as potential early biomarkers of declining brain health. The aim of this chapter is to provide an overview of approaches used to measure CBF for determining resting cerebral tissue perfusion and functional CBF responsiveness. We will highlight the strengths and weaknesses of each and illustrate the methodological differences that need to be considered when assessing brain vascular health. The imaging methods measuring CBF will cover: Doppler ultrasound (spanning transcranial Doppler (TCD), duplex ultrasound, and transcranial color Doppler (TCCD)), magnetic resonance imaging (MRI) (including arterial spin labeling (ASL), blood oxygenation level dependent (BOLD) signal measures and phase-contrast angiography), and finally near-infrared spectroscopy (NIRS).",

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AU - Burley, Claire

AU - Mullinger, Karen

AU - Thomas, Kate N

AU - Rendeiro, Catarina

AU - Dehghani, Hamid

AU - Lucas, Sam

PY - 2021/6/18

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N2 - Cerebral blood flow (CBF) measures are used in clinical settings to diagnose conditions (e.g., vasospasms, sickle cell disease, stroke, dementia, confirmation of brain death), as well as in research, emerging as potential early biomarkers of declining brain health. The aim of this chapter is to provide an overview of approaches used to measure CBF for determining resting cerebral tissue perfusion and functional CBF responsiveness. We will highlight the strengths and weaknesses of each and illustrate the methodological differences that need to be considered when assessing brain vascular health. The imaging methods measuring CBF will cover: Doppler ultrasound (spanning transcranial Doppler (TCD), duplex ultrasound, and transcranial color Doppler (TCCD)), magnetic resonance imaging (MRI) (including arterial spin labeling (ASL), blood oxygenation level dependent (BOLD) signal measures and phase-contrast angiography), and finally near-infrared spectroscopy (NIRS).

AB - Cerebral blood flow (CBF) measures are used in clinical settings to diagnose conditions (e.g., vasospasms, sickle cell disease, stroke, dementia, confirmation of brain death), as well as in research, emerging as potential early biomarkers of declining brain health. The aim of this chapter is to provide an overview of approaches used to measure CBF for determining resting cerebral tissue perfusion and functional CBF responsiveness. We will highlight the strengths and weaknesses of each and illustrate the methodological differences that need to be considered when assessing brain vascular health. The imaging methods measuring CBF will cover: Doppler ultrasound (spanning transcranial Doppler (TCD), duplex ultrasound, and transcranial color Doppler (TCCD)), magnetic resonance imaging (MRI) (including arterial spin labeling (ASL), blood oxygenation level dependent (BOLD) signal measures and phase-contrast angiography), and finally near-infrared spectroscopy (NIRS).

KW - Cerebral blood flow

KW - Transcranial Doppler

KW - Duplex ultrasound

KW - Magnetic resonance imaging

KW - Near-infrared spectroscopy

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BT - Reference Module in Neuroscience and Biobehavioral Psychology

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ER -

Imaging cerebral blood flow for brain health measurement

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