IL-6 muscles in on the gut and pancreas to enhance insulin secretion

Tamara L Allen; Martin Whitham; Mark A Febbraio

doi:10.1016/j.cmet.2011.12.004

IL-6 muscles in on the gut and pancreas to enhance insulin secretion

Tamara L Allen
, Martin Whitham
, Mark A Febbraio

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The role of the cytokine interleukin-6 (IL-6) in metabolic homeostasis is the subject of conjecture. Recent work in Nature Medicine (Ellingsgaard et al., 2011) demonstrates that IL-6 released from skeletal muscle during exercise mediates crosstalk between insulin-sensitive tissues, intestinal L cells, and pancreatic islets to adapt to changes in insulin demand.

Original language	English
Pages (from-to)	8-9
Number of pages	2
Journal	Cell Metabolism
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2011.12.004
Publication status	Published - 4 Jan 2012
Externally published	Yes

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10.1016/j.cmet.2011.12.004

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title = "IL-6 muscles in on the gut and pancreas to enhance insulin secretion",

abstract = "The role of the cytokine interleukin-6 (IL-6) in metabolic homeostasis is the subject of conjecture. Recent work in Nature Medicine (Ellingsgaard et al., 2011) demonstrates that IL-6 released from skeletal muscle during exercise mediates crosstalk between insulin-sensitive tissues, intestinal L cells, and pancreatic islets to adapt to changes in insulin demand.",

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AU - Febbraio, Mark A

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AB - The role of the cytokine interleukin-6 (IL-6) in metabolic homeostasis is the subject of conjecture. Recent work in Nature Medicine (Ellingsgaard et al., 2011) demonstrates that IL-6 released from skeletal muscle during exercise mediates crosstalk between insulin-sensitive tissues, intestinal L cells, and pancreatic islets to adapt to changes in insulin demand.

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DO - 10.1016/j.cmet.2011.12.004

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VL - 15

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JO - Cell Metabolism

JF - Cell Metabolism

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IL-6 muscles in on the gut and pancreas to enhance insulin secretion

Abstract

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