IL-6 muscles in on the gut and pancreas to enhance insulin secretion

Tamara L Allen, Martin Whitham, Mark A Febbraio

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The role of the cytokine interleukin-6 (IL-6) in metabolic homeostasis is the subject of conjecture. Recent work in Nature Medicine (Ellingsgaard et al., 2011) demonstrates that IL-6 released from skeletal muscle during exercise mediates crosstalk between insulin-sensitive tissues, intestinal L cells, and pancreatic islets to adapt to changes in insulin demand.

Original languageEnglish
Pages (from-to)8-9
Number of pages2
JournalCell Metabolism
Volume15
Issue number1
DOIs
Publication statusPublished - 4 Jan 2012
Externally publishedYes

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