IFN-α and IFN-β: a link between immune memory and chronic inflammation

AN Akbar, Janet Lord, Michael Salmon

Research output: Contribution to journalArticle

118 Citations (Scopus)


The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.
Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalImmunology Today
Issue number7
Publication statusPublished - 1 Jul 2000


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