Abstract
The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.
Original language | English |
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Pages (from-to) | 337-342 |
Number of pages | 6 |
Journal | Immunology Today |
Volume | 21 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2000 |