Identifying cases of type 2 diabetes in heterogeneous data sources: strategy from the EMIF project

Giuseppe Roberto, Ingrid Leal, Naveed Sattar, A. Katrina Loomis, Paul Avillach, Peter Egger, Rients Van Wijngaarden, David Ansell, Sulev Reisberg, Mari-liis Tammesoo, Helene Alavere, Alessandro Pasqua, Lars Pedersen, James Cunningham, Lara Tramontan, Miguel A. Mayer, Ron Herings, Preciosa Coloma, Francesco Lapi, Miriam SturkenboomJohan Van Der Lei, Martijn J. Schuemie, Peter Rijnbeek, Rosa Gini, Gianni Virgili (Editor)

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
123 Downloads (Pure)


Due to the heterogeneity of existing European sources of observational healthcare data, data source-tailored choices are needed to execute multi-data source, multi-national epidemiological studies. This makes transparent documentation paramount. In this proof-of-concept study, a novel standard data derivation procedure was tested in a set of heterogeneous data sources. Identification of subjects with type 2 diabetes (T2DM) was the test case. We included three primary care data sources (PCDs), three record linkage of administrative and/or registry data sources (RLDs), one hospital and one biobank. Overall, data from 12 million subjects from six European countries were extracted. Based on a shared event definition, sixteeen standard algorithms (components) useful to identify T2DM cases were generated through a top-down/bottom-up iterative approach. Each component was based on one single data domain among diagnoses, drugs, diagnostic test utilization and laboratory results. Diagnoses-based components were subclassified considering the healthcare setting (primary, secondary, inpatient care). The Unified Medical Language System was used for semantic harmonization within data domains. Individual components were extracted and proportion of population identified was compared across data sources. Drug-based components performed similarly in RLDs and PCDs, unlike diagnoses-based components. Using components as building blocks, logical combinations with AND, OR, AND NOT were tested and local experts recommended their preferred data source-tailored combination. The population identified per data sources by resulting algorithms varied from 3.5% to 15.7%, however, age-specific results were fairly comparable. The impact of individual components was assessed: diagnoses-based components identified the majority of cases in PCDs (93-100%), while drug-based components were the main contributors in RLDs (81-100%). The proposed data derivation procedure allowed the generation of data source-tailored case-finding algorithms in a standardized fashion, facilitated transparent documentation of the process and benchmarking of data sources, and provided bases for interpretation of possible inter-data source inconsistency of findings in future studies.
Original languageEnglish
Article numbere0160648
Number of pages18
JournalPLoS ONE
Issue number8
Publication statusPublished - 31 Aug 2016


Dive into the research topics of 'Identifying cases of type 2 diabetes in heterogeneous data sources: strategy from the EMIF project'. Together they form a unique fingerprint.

Cite this