Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

M. Medici; E. Porcu; G. Pistis; A. Teumer; S.J. Brown; R.A. Jensen; R. Rawal; G.L. Roef; T.S. Plantinga; S.H. Vermeulen; J. Lahti; M.J. Simmonds; L.L.N. Husemoen; R.M. Freathy; B.M. Shields; D. Pietzner; R. Nagy; L. Broer; L. Chaker; T.I.M. Korevaar; M.G. Plia; C. Sala; U. Völker; J.B. Richards; F.C. Sweep; C. Gieger; T. Corre; E. Kajantie; B. Thuesen; Y.E. Taes; W.E. Visser; A.T. Hattersley; J. Kratzsch; A. Hamilton; W. Li; G. Homuth; M. Lobina; S. Mariotti; N. Soranzo; M. Cocca; M. Nauck; C. Spielhagen; A. Ross; A. Arnold; M. van de Bunt; S. Liyanarachchi; M. Heier; H.J. Grabe; C. Masciullo; T.E. Galesloot; E.M. Lim; E. Reischl; P.J. Leedman; S. Lai; A. Delitala; A.P. Bremner; D.I.W. Philips; J.P. Beilby; A. Mulas; M. Vocale; G. Abecasis; T. Forsen; A. James; E. Widen; J. Hui; H. Prokisch; E.E. Rietzschel; A. Palotie; P. Feddema; S.J. Fletcher; K. Schramm; J.I. Rotter; A. Kluttig; D. Radke; M. Traglia; G.L. Surdulescu; H. He; J.A. Franklyn; D. Tiller; B. Vaidya; T. de Meyer; T. Jørgensen; J.G. Eriksson; P.C. O'Leary; E. Wichmann; A.R. Hermus; B.M. Psaty; T. Ittermann; A. Hofman; E. Bosi; D. Schlessinger; H. Wallaschofski; N. Pirastu; Y.S. Aulchenko; A. de la Chapelle; R.T. Netea-Maier; S.C.L. Gough; H. Meyer zu Schwabedissen; T.M. Frayling; J.-M. Kaufman; A. Linneberg; K. Räikkönen; J.W.A. Smit; L.A. Kiemeney; F. Rivadeneira; A.G. Uitterlinden; J.P. Walsh; C. Meisinger; M. den Heijer; T.J. Visser; T.D. Spector; S.G. Wilson; H. Völzke; A. Cappola; D. Toniolo; S. Sanna; S. Naitza; R.P. Peeters

doi:10.1371/journal.pgen.1004123

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

M. Medici, E. Porcu, G. Pistis, A. Teumer, S.J. Brown, R.A. Jensen, R. Rawal, G.L. Roef, T.S. Plantinga, S.H. Vermeulen, J. Lahti, M.J. Simmonds, L.L.N. Husemoen, R.M. Freathy, B.M. Shields, D. Pietzner, R. Nagy, L. Broer, L. Chaker, T.I.M. KorevaarM.G. Plia, C. Sala, U. Völker, J.B. Richards, F.C. Sweep, C. Gieger, T. Corre, E. Kajantie, B. Thuesen, Y.E. Taes, W.E. Visser, A.T. Hattersley, J. Kratzsch, A. Hamilton, W. Li, G. Homuth, M. Lobina, S. Mariotti, N. Soranzo, M. Cocca, M. Nauck, C. Spielhagen, A. Ross, A. Arnold, M. van de Bunt, S. Liyanarachchi, M. Heier, H.J. Grabe, C. Masciullo, T.E. Galesloot, E.M. Lim, E. Reischl, P.J. Leedman, S. Lai, A. Delitala, A.P. Bremner, D.I.W. Philips, J.P. Beilby, A. Mulas, M. Vocale, G. Abecasis, T. Forsen, A. James, E. Widen, J. Hui, H. Prokisch, E.E. Rietzschel, A. Palotie, P. Feddema, S.J. Fletcher, K. Schramm, J.I. Rotter, A. Kluttig, D. Radke, M. Traglia, G.L. Surdulescu, H. He, J.A. Franklyn, D. Tiller, B. Vaidya, T. de Meyer, T. Jørgensen, J.G. Eriksson, P.C. O'Leary, E. Wichmann, A.R. Hermus, B.M. Psaty, T. Ittermann, A. Hofman, E. Bosi, D. Schlessinger, H. Wallaschofski, N. Pirastu, Y.S. Aulchenko, A. de la Chapelle, R.T. Netea-Maier, S.C.L. Gough, H. Meyer zu Schwabedissen, T.M. Frayling, J.-M. Kaufman, A. Linneberg, K. Räikkönen, J.W.A. Smit, L.A. Kiemeney, F. Rivadeneira, A.G. Uitterlinden, J.P. Walsh, C. Meisinger, M. den Heijer, T.J. Visser, T.D. Spector, S.G. Wilson, H. Völzke, A. Cappola, D. Toniolo, S. Sanna, S. Naitza, R.P. Peeters

Birmingham Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P

Original language	English
Article number	e1004123
Journal	PLoS Genetics
Volume	10
Issue number	2
DOIs	https://doi.org/10.1371/journal.pgen.1004123
Publication status	Published - 27 Feb 2014

Keywords

thyroid peroxidase antibody
thyrotropin
adult
aged
antibody blood level
article
ATXN2 gene
autoimmune disease
autoimmune thyroid disease
autoimmunity
Bach2 gene
cancer risk
controlled study
female
gene
gene frequency
gene identification
gene locus
genetic association
genetic variability
goiter
Graves disease
Hashimoto disease
human
kalrn gene
MAGI3 gene
major clinical study
male
risk assessment
risk factor
risk reduction
scoring system
single nucleotide polymorphism
subclinical hyperthyroidism
subclinical hypothyroidism
thyroid cancer
thyroid disease
TPO gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pgen.1004123

Franklyn_Identification_novel_genetic_loci_PLOS_Genetics_2014
Eligibility for repository : checked 17/06/2014
Final published version, 920 KBLicence: Creative Commons: Attribution (CC BY)

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Medici, M., Porcu, E., Pistis, G., Teumer, A., Brown, S. J., Jensen, R. A., Rawal, R., Roef, G. L., Plantinga, T. S., Vermeulen, S. H., Lahti, J., Simmonds, M. J., Husemoen, L. L. N., Freathy, R. M., Shields, B. M., Pietzner, D., Nagy, R., Broer, L., Chaker, L., ... Peeters, R. P. (2014). Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genetics, 10(2), [e1004123]. https://doi.org/10.1371/journal.pgen.1004123

@article{40e50e13db6541eea9d665eb6eddff34,

title = "Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease",

abstract = "Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P",

keywords = "thyroid peroxidase antibody, thyrotropin, adult, aged, antibody blood level, article, ATXN2 gene, autoimmune disease, autoimmune thyroid disease, autoimmunity, Bach2 gene, cancer risk, controlled study, female, gene, gene frequency, gene identification, gene locus, genetic association, genetic variability, goiter, Graves disease, Hashimoto disease, human, kalrn gene, MAGI3 gene, major clinical study, male, risk assessment, risk factor, risk reduction, scoring system, single nucleotide polymorphism, subclinical hyperthyroidism, subclinical hypothyroidism, thyroid cancer, thyroid disease, TPO gene",

author = "M. Medici and E. Porcu and G. Pistis and A. Teumer and S.J. Brown and R.A. Jensen and R. Rawal and G.L. Roef and T.S. Plantinga and S.H. Vermeulen and J. Lahti and M.J. Simmonds and L.L.N. Husemoen and R.M. Freathy and B.M. Shields and D. Pietzner and R. Nagy and L. Broer and L. Chaker and T.I.M. Korevaar and M.G. Plia and C. Sala and U. V{\"o}lker and J.B. Richards and F.C. Sweep and C. Gieger and T. Corre and E. Kajantie and B. Thuesen and Y.E. Taes and W.E. Visser and A.T. Hattersley and J. Kratzsch and A. Hamilton and W. Li and G. Homuth and M. Lobina and S. Mariotti and N. Soranzo and M. Cocca and M. Nauck and C. Spielhagen and A. Ross and A. Arnold and {van de Bunt}, M. and S. Liyanarachchi and M. Heier and H.J. Grabe and C. Masciullo and T.E. Galesloot and E.M. Lim and E. Reischl and P.J. Leedman and S. Lai and A. Delitala and A.P. Bremner and D.I.W. Philips and J.P. Beilby and A. Mulas and M. Vocale and G. Abecasis and T. Forsen and A. James and E. Widen and J. Hui and H. Prokisch and E.E. Rietzschel and A. Palotie and P. Feddema and S.J. Fletcher and K. Schramm and J.I. Rotter and A. Kluttig and D. Radke and M. Traglia and G.L. Surdulescu and H. He and J.A. Franklyn and D. Tiller and B. Vaidya and {de Meyer}, T. and T. J{\o}rgensen and J.G. Eriksson and P.C. O'Leary and E. Wichmann and A.R. Hermus and B.M. Psaty and T. Ittermann and A. Hofman and E. Bosi and D. Schlessinger and H. Wallaschofski and N. Pirastu and Y.S. Aulchenko and {de la Chapelle}, A. and R.T. Netea-Maier and S.C.L. Gough and {Meyer zu Schwabedissen}, H. and T.M. Frayling and J.-M. Kaufman and A. Linneberg and K. R{\"a}ikk{\"o}nen and J.W.A. Smit and L.A. Kiemeney and F. Rivadeneira and A.G. Uitterlinden and J.P. Walsh and C. Meisinger and {den Heijer}, M. and T.J. Visser and T.D. Spector and S.G. Wilson and H. V{\"o}lzke and A. Cappola and D. Toniolo and S. Sanna and S. Naitza and R.P. Peeters",

year = "2014",

month = feb,

day = "27",

doi = "10.1371/journal.pgen.1004123",

language = "English",

volume = "10",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science (PLOS)",

number = "2",

}

Medici, M, Porcu, E, Pistis, G, Teumer, A, Brown, SJ, Jensen, RA, Rawal, R, Roef, GL, Plantinga, TS, Vermeulen, SH, Lahti, J, Simmonds, MJ, Husemoen, LLN, Freathy, RM, Shields, BM, Pietzner, D, Nagy, R, Broer, L, Chaker, L, Korevaar, TIM, Plia, MG, Sala, C, Völker, U, Richards, JB, Sweep, FC, Gieger, C, Corre, T, Kajantie, E, Thuesen, B, Taes, YE, Visser, WE, Hattersley, AT, Kratzsch, J, Hamilton, A, Li, W, Homuth, G, Lobina, M, Mariotti, S, Soranzo, N, Cocca, M, Nauck, M, Spielhagen, C, Ross, A, Arnold, A, van de Bunt, M, Liyanarachchi, S, Heier, M, Grabe, HJ, Masciullo, C, Galesloot, TE, Lim, EM, Reischl, E, Leedman, PJ, Lai, S, Delitala, A, Bremner, AP, Philips, DIW, Beilby, JP, Mulas, A, Vocale, M, Abecasis, G, Forsen, T, James, A, Widen, E, Hui, J, Prokisch, H, Rietzschel, EE, Palotie, A, Feddema, P, Fletcher, SJ, Schramm, K, Rotter, JI, Kluttig, A, Radke, D, Traglia, M, Surdulescu, GL, He, H, Franklyn, JA, Tiller, D, Vaidya, B, de Meyer, T, Jørgensen, T, Eriksson, JG, O'Leary, PC, Wichmann, E, Hermus, AR, Psaty, BM, Ittermann, T, Hofman, A, Bosi, E, Schlessinger, D, Wallaschofski, H, Pirastu, N, Aulchenko, YS, de la Chapelle, A, Netea-Maier, RT, Gough, SCL, Meyer zu Schwabedissen, H, Frayling, TM, Kaufman, J-M, Linneberg, A, Räikkönen, K, Smit, JWA, Kiemeney, LA, Rivadeneira, F, Uitterlinden, AG, Walsh, JP, Meisinger, C, den Heijer, M, Visser, TJ, Spector, TD, Wilson, SG, Völzke, H, Cappola, A, Toniolo, D, Sanna, S, Naitza, S & Peeters, RP 2014, 'Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease', PLoS Genetics, vol. 10, no. 2, e1004123. https://doi.org/10.1371/journal.pgen.1004123

TY - JOUR

T1 - Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

AU - Medici, M.

AU - Porcu, E.

AU - Pistis, G.

AU - Teumer, A.

AU - Brown, S.J.

AU - Jensen, R.A.

AU - Rawal, R.

AU - Roef, G.L.

AU - Plantinga, T.S.

AU - Vermeulen, S.H.

AU - Lahti, J.

AU - Simmonds, M.J.

AU - Husemoen, L.L.N.

AU - Freathy, R.M.

AU - Shields, B.M.

AU - Pietzner, D.

AU - Nagy, R.

AU - Broer, L.

AU - Chaker, L.

AU - Korevaar, T.I.M.

AU - Plia, M.G.

AU - Sala, C.

AU - Völker, U.

AU - Richards, J.B.

AU - Sweep, F.C.

AU - Gieger, C.

AU - Corre, T.

AU - Kajantie, E.

AU - Thuesen, B.

AU - Taes, Y.E.

AU - Visser, W.E.

AU - Hattersley, A.T.

AU - Kratzsch, J.

AU - Hamilton, A.

AU - Li, W.

AU - Homuth, G.

AU - Lobina, M.

AU - Mariotti, S.

AU - Soranzo, N.

AU - Cocca, M.

AU - Nauck, M.

AU - Spielhagen, C.

AU - Ross, A.

AU - Arnold, A.

AU - van de Bunt, M.

AU - Liyanarachchi, S.

AU - Heier, M.

AU - Grabe, H.J.

AU - Masciullo, C.

AU - Galesloot, T.E.

AU - Lim, E.M.

AU - Reischl, E.

AU - Leedman, P.J.

AU - Lai, S.

AU - Delitala, A.

AU - Bremner, A.P.

AU - Philips, D.I.W.

AU - Beilby, J.P.

AU - Mulas, A.

AU - Vocale, M.

AU - Abecasis, G.

AU - Forsen, T.

AU - James, A.

AU - Widen, E.

AU - Hui, J.

AU - Prokisch, H.

AU - Rietzschel, E.E.

AU - Palotie, A.

AU - Feddema, P.

AU - Fletcher, S.J.

AU - Schramm, K.

AU - Rotter, J.I.

AU - Kluttig, A.

AU - Radke, D.

AU - Traglia, M.

AU - Surdulescu, G.L.

AU - He, H.

AU - Franklyn, J.A.

AU - Tiller, D.

AU - Vaidya, B.

AU - de Meyer, T.

AU - Jørgensen, T.

AU - Eriksson, J.G.

AU - O'Leary, P.C.

AU - Wichmann, E.

AU - Hermus, A.R.

AU - Psaty, B.M.

AU - Ittermann, T.

AU - Hofman, A.

AU - Bosi, E.

AU - Schlessinger, D.

AU - Wallaschofski, H.

AU - Pirastu, N.

AU - Aulchenko, Y.S.

AU - de la Chapelle, A.

AU - Netea-Maier, R.T.

AU - Gough, S.C.L.

AU - Meyer zu Schwabedissen, H.

AU - Frayling, T.M.

AU - Kaufman, J.-M.

AU - Linneberg, A.

AU - Räikkönen, K.

AU - Smit, J.W.A.

AU - Kiemeney, L.A.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - Walsh, J.P.

AU - Meisinger, C.

AU - den Heijer, M.

AU - Visser, T.J.

AU - Spector, T.D.

AU - Wilson, S.G.

AU - Völzke, H.

AU - Cappola, A.

AU - Toniolo, D.

AU - Sanna, S.

AU - Naitza, S.

AU - Peeters, R.P.

PY - 2014/2/27

Y1 - 2014/2/27

N2 - Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P

AB - Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P

KW - thyroid peroxidase antibody

KW - thyrotropin

KW - adult

KW - aged

KW - antibody blood level

KW - article

KW - ATXN2 gene

KW - autoimmune disease

KW - autoimmune thyroid disease

KW - autoimmunity

KW - Bach2 gene

KW - cancer risk

KW - controlled study

KW - female

KW - gene

KW - gene frequency

KW - gene identification

KW - gene locus

KW - genetic association

KW - genetic variability

KW - goiter

KW - Graves disease

KW - Hashimoto disease

KW - human

KW - kalrn gene

KW - MAGI3 gene

KW - major clinical study

KW - male

KW - risk assessment

KW - risk factor

KW - risk reduction

KW - scoring system

KW - single nucleotide polymorphism

KW - subclinical hyperthyroidism

KW - subclinical hypothyroidism

KW - thyroid cancer

KW - thyroid disease

KW - TPO gene

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84901741541&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1004123

DO - 10.1371/journal.pgen.1004123

M3 - Article

C2 - 24586183

AN - SCOPUS:84901741541

SN - 1553-7390

VL - 10

JO - PLoS Genetics

JF - PLoS Genetics

IS - 2

M1 - e1004123

ER -

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

Abstract

Keywords

UN SDGs

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