Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

Debasmita Sarkar; M Sidhu; Albel Singh; J Chen; David Lammas; A van der Saar; Gurdyal Besra; Apoorva Bhatt

doi:10.1128/JB.00065-11

Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

Debasmita Sarkar, M Sidhu, Albel Singh, J Chen, David Lammas, A van der Saar, Gurdyal Besra, Apoorva Bhatt

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Abstract

Deletion of M. marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides. The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

Original language	English
Journal	Journal of Bacteriology
DOIs	https://doi.org/10.1128/JB.00065-11
Publication status	Published - 4 Mar 2011

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title = "Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.",

abstract = "Deletion of M. marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides. The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.",

author = "Debasmita Sarkar and M Sidhu and Albel Singh and J Chen and David Lammas and {van der Saar}, A and Gurdyal Besra and Apoorva Bhatt",

year = "2011",

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doi = "10.1128/JB.00065-11",

language = "English",

journal = "Journal of Bacteriology",

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T1 - Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

AU - Sarkar, Debasmita

AU - Sidhu, M

AU - Singh, Albel

AU - Chen, J

AU - Lammas, David

AU - van der Saar, A

AU - Besra, Gurdyal

AU - Bhatt, Apoorva

PY - 2011/3/4

Y1 - 2011/3/4

N2 - Deletion of M. marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides. The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

AB - Deletion of M. marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides. The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

U2 - 10.1128/JB.00065-11

DO - 10.1128/JB.00065-11

M3 - Article

C2 - 21378187

JO - Journal of Bacteriology

JF - Journal of Bacteriology

ER -

Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

Abstract

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