Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.

Abdul Maher; AB Milsom; P Gunaruwan; Khalid Abozguia; Ibrar Ahmed; Rebekah Weaver; P Thomas; H Ashrafian; Gustav Born; PE James; Michael Frenneaux

doi:10.1161/CIRCULATIONAHA.107.719591

Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.

Abdul Maher, AB Milsom, P Gunaruwan, Khalid Abozguia, Ibrar Ahmed, Rebekah Weaver, P Thomas, H Ashrafian, Gustav Born, PE James, Michael Frenneaux

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169 Citations (Scopus)

Abstract

BACKGROUND: It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia. The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia. METHODS AND RESULTS: Forty healthy volunteers were studied. After baseline infusion of 0.9% saline, sodium nitrite was infused at incremental doses from 40 nmol/min to 7.84 mumol/min. At each stage, forearm blood flow was measured by strain-gauge plethysmography. Forearm venous volume was assessed by radionuclide plethysmography. Changes in forearm blood flow and forearm venous volume in the infused arm were corrected for those in the control arm. The peak percentage of venodilation during normoxia was 35.8+/-3.4% (mean+/-SEM) at 7.84 micromol/min (P

Original language	English
Pages (from-to)	670-7
Number of pages	8
Journal	Circulation
Volume	117
Issue number	5
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.107.719591
Publication status	Published - 5 Feb 2008

Keywords

nitric oxide
hypoxia
heart failure
veins
vasodilation
nitrites

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10.1161/CIRCULATIONAHA.107.719591

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title = "Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.",

abstract = "BACKGROUND: It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia. The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia. METHODS AND RESULTS: Forty healthy volunteers were studied. After baseline infusion of 0.9% saline, sodium nitrite was infused at incremental doses from 40 nmol/min to 7.84 mumol/min. At each stage, forearm blood flow was measured by strain-gauge plethysmography. Forearm venous volume was assessed by radionuclide plethysmography. Changes in forearm blood flow and forearm venous volume in the infused arm were corrected for those in the control arm. The peak percentage of venodilation during normoxia was 35.8+/-3.4% (mean+/-SEM) at 7.84 micromol/min (P",

keywords = "nitric oxide, hypoxia, heart failure, veins, vasodilation, nitrites",

author = "Abdul Maher and AB Milsom and P Gunaruwan and Khalid Abozguia and Ibrar Ahmed and Rebekah Weaver and P Thomas and H Ashrafian and Gustav Born and PE James and Michael Frenneaux",

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T1 - Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.

AU - Maher, Abdul

AU - Milsom, AB

AU - Gunaruwan, P

AU - Abozguia, Khalid

AU - Ahmed, Ibrar

AU - Weaver, Rebekah

AU - Thomas, P

AU - Ashrafian, H

AU - Born, Gustav

AU - James, PE

AU - Frenneaux, Michael

PY - 2008/2/5

Y1 - 2008/2/5

N2 - BACKGROUND: It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia. The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia. METHODS AND RESULTS: Forty healthy volunteers were studied. After baseline infusion of 0.9% saline, sodium nitrite was infused at incremental doses from 40 nmol/min to 7.84 mumol/min. At each stage, forearm blood flow was measured by strain-gauge plethysmography. Forearm venous volume was assessed by radionuclide plethysmography. Changes in forearm blood flow and forearm venous volume in the infused arm were corrected for those in the control arm. The peak percentage of venodilation during normoxia was 35.8+/-3.4% (mean+/-SEM) at 7.84 micromol/min (P

AB - BACKGROUND: It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia. The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia. METHODS AND RESULTS: Forty healthy volunteers were studied. After baseline infusion of 0.9% saline, sodium nitrite was infused at incremental doses from 40 nmol/min to 7.84 mumol/min. At each stage, forearm blood flow was measured by strain-gauge plethysmography. Forearm venous volume was assessed by radionuclide plethysmography. Changes in forearm blood flow and forearm venous volume in the infused arm were corrected for those in the control arm. The peak percentage of venodilation during normoxia was 35.8+/-3.4% (mean+/-SEM) at 7.84 micromol/min (P

KW - nitric oxide

KW - hypoxia

KW - heart failure

KW - veins

KW - vasodilation

KW - nitrites

U2 - 10.1161/CIRCULATIONAHA.107.719591

DO - 10.1161/CIRCULATIONAHA.107.719591

M3 - Article

C2 - 18212289

SN - 1524-4539

VL - 117

SP - 670

EP - 677

JO - Circulation

JF - Circulation

IS - 5

ER -

Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.

Abstract

Keywords

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