Hypothermia in VGKC antibody-associated limbic encephalitis

S Jacob, S R Irani, Y A Rajabally, A Grubneac, R J Walters, M Yazaki, L Clover, A Vincent

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37 Citations (Scopus)


Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures.

Original languageEnglish
Pages (from-to)202-4
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number2
Publication statusPublished - Feb 2008


  • Aged
  • Atrophy
  • Autoantibodies/blood
  • Azathioprine/adverse effects
  • Cyclosporine/adverse effects
  • Dominance, Cerebral/physiology
  • Epilepsy, Temporal Lobe/etiology
  • Female
  • Hippocampus/pathology
  • Humans
  • Hypothalamus/pathology
  • Hypothermia/etiology
  • Immunization, Passive
  • Immunosuppressive Agents/adverse effects
  • Limbic Encephalitis/diagnosis
  • Low Back Pain/immunology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Plasma Exchange
  • Potassium Channels, Voltage-Gated/immunology
  • Prednisolone/adverse effects
  • Recurrence
  • Retreatment
  • Temporal Lobe/pathology
  • Thymoma/diagnosis
  • Thymus Neoplasms/diagnosis


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