Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Francis J Mussai; Lea C Cunningham; Geoffrey Rezvani; Constantine A Stratakis; James C Reynolds; Galina Nesterova; Robert M Henshaw; Jason E Levine; Lee J Helman; Diane C Arthur; Su Young Kim

doi:10.1097/MPH.0b013e318168f072

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Francis J Mussai, Lea C Cunningham, Geoffrey Rezvani, Constantine A Stratakis, James C Reynolds, Galina Nesterova, Robert M Henshaw, Jason E Levine, Lee J Helman, Diane C Arthur, Su Young Kim

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

Original language	English
Pages (from-to)	612-7
Number of pages	6
Journal	Journal of pediatric hematology/oncology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1097/MPH.0b013e318168f072
Publication status	Published - 2008

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title = "Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome",

abstract = "Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.",

author = "Mussai, {Francis J} and Cunningham, {Lea C} and Geoffrey Rezvani and Stratakis, {Constantine A} and Reynolds, {James C} and Galina Nesterova and Henshaw, {Robert M} and Levine, {Jason E} and Helman, {Lee J} and Arthur, {Diane C} and Kim, {Su Young}",

year = "2008",

doi = "10.1097/MPH.0b013e318168f072",

language = "English",

volume = "30",

pages = "612--7",

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TY - JOUR

T1 - Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

AU - Mussai, Francis J

AU - Cunningham, Lea C

AU - Rezvani, Geoffrey

AU - Stratakis, Constantine A

AU - Reynolds, James C

AU - Nesterova, Galina

AU - Henshaw, Robert M

AU - Levine, Jason E

AU - Helman, Lee J

AU - Arthur, Diane C

AU - Kim, Su Young

PY - 2008

Y1 - 2008

N2 - Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

AB - Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

U2 - 10.1097/MPH.0b013e318168f072

DO - 10.1097/MPH.0b013e318168f072

M3 - Article

C2 - 18799940

SN - 1536-3678

VL - 30

SP - 612

EP - 617

JO - Journal of pediatric hematology/oncology

JF - Journal of pediatric hematology/oncology

IS - 8

ER -

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Abstract

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