Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Francis J Mussai, Lea C Cunningham, Geoffrey Rezvani, Constantine A Stratakis, James C Reynolds, Galina Nesterova, Robert M Henshaw, Jason E Levine, Lee J Helman, Diane C Arthur, Su Young Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.
Original languageEnglish
Pages (from-to)612-7
Number of pages6
JournalJournal of pediatric hematology/oncology
Issue number8
Publication statusPublished - 2008


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