Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial

Katarina Witt, Lee Beresford, Siladitya Bhattacharya, Kate Brian, Aravinthan Coomarasamy, Richard Hooper, Jackson Kirkman-Brown, Yakoub Khalaf, Sheena Lewis, Allan Pacey, Sue Pavitt, Robert West, David Miller

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Abstract

The selection of a sperm with good genomic integrity is an important consideration
for improving Intra-Cytoplasmic Sperm Injection (ICSI) outcome. Current convention
selects sperm by vigour and morphology, but preliminary evidence suggests
selection based on hyaluronic acid bidning may be beneficial. The aim of the
HABSelect trial is to determine the efficacy of HA-selection of sperm versus
conventionally selected sperm prior to ICSI on live birth rate (LBR). The mechanistic
aim is to assess whether and how the chromatin state of HA-selected sperm
corresponds with clinical outcomes – clinical pregnancy rate (CPR), LBR and
pregnancy loss (PL).
Original languageEnglish
Article numbere012609
JournalBMJ open
Volume6
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

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