Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Lina Schiffer, Lise Barnard, Elizabeth Baranowski, Lorna Gilligan, Angela Taylor, Wiebke Arlt, Cedric Shackleton, Karl-Heinz Storbeck

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)
584 Downloads (Pure)

Abstract

Advances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the serum and urine steroid metabolomes. The quantification of steroid panels is therefore gaining favor over quantification of single marker metabolites in the clinical and research laboratories. However, although the biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still exists between this knowledge and its application to the measured steroid profiles. In this review, we present an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview of the methodology used in steroid profiling is also provided.

Original languageEnglish
Article number105439
Number of pages25
JournalThe Journal of Steroid Biochemistry and Molecular Biology
Volume194
Early online date27 Jul 2019
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • Serum metabolome
  • Steroid biosynthesis
  • Steroid metabolism
  • Steroid metabolome
  • Urine metabolome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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