Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Lina Schiffer; Lise Barnard; Elizabeth Baranowski; Lorna Gilligan; Angela Taylor; Wiebke Arlt; Cedric Shackleton; Karl-Heinz Storbeck

doi:10.1016/j.jsbmb.2019.105439

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Lina Schiffer, Lise Barnard, Elizabeth Baranowski, Lorna Gilligan, Angela Taylor, Wiebke Arlt, Cedric Shackleton, Karl-Heinz Storbeck

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Abstract

Advances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the serum and urine steroid metabolomes. The quantification of steroid panels is therefore gaining favor over quantification of single marker metabolites in the clinical and research laboratories. However, although the biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still exists between this knowledge and its application to the measured steroid profiles. In this review, we present an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview of the methodology used in steroid profiling is also provided.

Original language	English
Article number	105439
Number of pages	25
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Volume	194
Early online date	27 Jul 2019
DOIs	https://doi.org/10.1016/j.jsbmb.2019.105439
Publication status	Published - 1 Nov 2019

Keywords

Serum metabolome
Steroid biosynthesis
Steroid metabolism
Steroid metabolome
Urine metabolome

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jsbmb.2019.105439Licence: Creative Commons: Attribution (CC BY)

Schiffer_et_al_Human_steroid_biosynthesis_metabolism_and_excretion_Journal_of_Steroid_Biochemistry_&_Molecular_Biology_2019
Schiffer, L, Barnard, L, Baranowski, E, Gilligan, L, Taylor, A, Arlt, W, Shackleton, C & Storbeck, K-H. (2019) 'Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review', The Journal of Steroid Biochemistry and Molecular Biology, vol. 194, 105439, pp. 1-25. https://doi.org/10.1016/j.jsbmb.2019.105439
Final published version, 7.13 MBLicence: Creative Commons: Attribution (CC BY)

https://www.sciencedirect.com/science/article/pii/S0960076019302791Licence: Creative Commons: Attribution (CC BY)

Cite this

Schiffer, L., Barnard, L., Baranowski, E., Gilligan, L., Taylor, A., Arlt, W., Shackleton, C., & Storbeck, K.-H. (2019). Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. The Journal of Steroid Biochemistry and Molecular Biology, 194, Article 105439. https://doi.org/10.1016/j.jsbmb.2019.105439

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Schiffer, L, Barnard, L, Baranowski, E, Gilligan, L, Taylor, A , Arlt, W, Shackleton, C & Storbeck, K-H 2019, 'Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review', The Journal of Steroid Biochemistry and Molecular Biology, vol. 194, 105439. https://doi.org/10.1016/j.jsbmb.2019.105439

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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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