Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Jan Piwowarski, Pawel Grzechnik, Andrzej Dziembowski, Aleksandra Dmochowska, Michal Minczuk, Piotr P. Stepien*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalJournal of Molecular Biology
Issue number5
Publication statusPublished - 20 Jun 2003
Externally publishedYes


  • Mitochondria
  • PNPase
  • Polynucleotide phosphorylase
  • RNA degradation

ASJC Scopus subject areas

  • Molecular Biology


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