Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Jan Piwowarski; Pawel Grzechnik; Andrzej Dziembowski; Aleksandra Dmochowska; Michal Minczuk; Piotr P. Stepien

doi:10.1016/S0022-2836(03)00528-X

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Jan Piwowarski, Pawel Grzechnik, Andrzej Dziembowski, Aleksandra Dmochowska, Michal Minczuk, Piotr P. Stepien^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

Original language	English
Pages (from-to)	853-857
Number of pages	5
Journal	Journal of Molecular Biology
Volume	329
Issue number	5
DOIs	https://doi.org/10.1016/S0022-2836(03)00528-X
Publication status	Published - 20 Jun 2003
Externally published	Yes

Keywords

Mitochondria
PNPase
Polynucleotide phosphorylase
RNA degradation

ASJC Scopus subject areas

Molecular Biology

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10.1016/S0022-2836(03)00528-X

Cite this

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abstract = "The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.",

keywords = "Mitochondria, PNPase, Polynucleotide phosphorylase, RNA degradation",

author = "Jan Piwowarski and Pawel Grzechnik and Andrzej Dziembowski and Aleksandra Dmochowska and Michal Minczuk and Stepien, {Piotr P.}",

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AU - Piwowarski, Jan

AU - Grzechnik, Pawel

AU - Dziembowski, Andrzej

AU - Dmochowska, Aleksandra

AU - Minczuk, Michal

AU - Stepien, Piotr P.

PY - 2003/6/20

Y1 - 2003/6/20

N2 - The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

AB - The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

KW - Mitochondria

KW - PNPase

KW - Polynucleotide phosphorylase

KW - RNA degradation

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U2 - 10.1016/S0022-2836(03)00528-X

DO - 10.1016/S0022-2836(03)00528-X

M3 - Article

C2 - 12798676

AN - SCOPUS:0037869109

SN - 0022-2836

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JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 5

ER -

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Abstract

Keywords

ASJC Scopus subject areas

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