Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease

Jasmeet S. Reyat; Yuqi Shen; Gowsihan Poologasundarampillai; Amirpasha Moetazedian; Julie Rayes; Abdullah O. Khan

doi:10.1161/CIRCRESAHA.125.326823

Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease

Jasmeet S. Reyat
, Yuqi Shen
, Gowsihan Poologasundarampillai
, Amirpasha Moetazedian
, Julie Rayes
, Abdullah O. Khan^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

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Original language	English
Pages (from-to)	1133-1136
Number of pages	4
Journal	Circulation Research
Volume	137
Issue number	8
Early online date	3 Sept 2025
DOIs	https://doi.org/10.1161/CIRCRESAHA.125.326823
Publication status	Published - 26 Sept 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

fibrosis
heart failure
microphysiological systems
myocytes, cardiac
organoids

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Access to Document

10.1161/CIRCRESAHA.125.326823Licence: Creative Commons: Attribution (CC BY)

ReyatJS2025HumanFinal published version, 3.45 MBLicence: Creative Commons: Attribution (CC BY)

1 Active
2 Finished

Extension Novel mechanism of platelet activation in haemolytic diseases
Rayes, J. (Principal Investigator)
British Heart Foundation
10/02/26 → 9/02/28
Project: Research
Novel mechanism of platelet activation in haemolytic diseases
Rayes, J. (Principal Investigator)
British Heart Foundation
1/02/21 → 31/01/26
Project: Research
Engineering a novel human bone marrow organoid to target myelofibrosis
Khan, A. (Principal Investigator)
The Wellcome Trust
1/05/20 → 30/04/24
Project: Research

Cite this

@article{b8bf9f28782141f192cd46824c229aa1,

title = "Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease",

keywords = "fibrosis, heart failure, microphysiological systems, myocytes, cardiac, organoids",

author = "Reyat, \{Jasmeet S.\} and Yuqi Shen and Gowsihan Poologasundarampillai and Amirpasha Moetazedian and Julie Rayes and Khan, \{Abdullah O.\}",

year = "2025",

month = sep,

day = "26",

doi = "10.1161/CIRCRESAHA.125.326823",

language = "English",

volume = "137",

pages = "1133--1136",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "American Heart Association",

number = "8",

}

TY - JOUR

T1 - Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease

AU - Reyat, Jasmeet S.

AU - Shen, Yuqi

AU - Poologasundarampillai, Gowsihan

AU - Moetazedian, Amirpasha

AU - Rayes, Julie

AU - Khan, Abdullah O.

PY - 2025/9/26

Y1 - 2025/9/26

KW - fibrosis

KW - heart failure

KW - microphysiological systems

KW - myocytes, cardiac

KW - organoids

U2 - 10.1161/CIRCRESAHA.125.326823

DO - 10.1161/CIRCRESAHA.125.326823

M3 - Letter

C2 - 40899259

AN - SCOPUS:105015882651

SN - 0009-7330

VL - 137

SP - 1133

EP - 1136

JO - Circulation Research

JF - Circulation Research

IS - 8

ER -

Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Projects

Extension Novel mechanism of platelet activation in haemolytic diseases

Novel mechanism of platelet activation in haemolytic diseases

Engineering a novel human bone marrow organoid to target myelofibrosis

Cite this