HOX genes in pancreatic development and cancer

Sophie Gray, Hardev S Pandha, Agnieszka Michael, Gary Middleton, Richard Morgan

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are subsequently re-expressed in many types of cancer. Some recent studies have shown that HOX genes may have key roles both in pancreatic development and in adult diseases of the pancreas, including cancer. In this review we consider recent advances in elucidating the role of HOX genes in these processes, how they may connect early developmental events to subsequent adult disease, and their potential both as diagnostic markers and therapeutic targets.
Original languageEnglish
Pages (from-to)216-9
Number of pages4
JournalJournal of the Pancreas
Issue number3
Publication statusPublished - 2011


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