How severe is diabetes after total pancreatectomy? A case-matched analysis

Keith J Roberts, Georgina Blanco, Jonathan Webber, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, Simon R Bramhall, John Isaac, Darius F Mirza

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)
164 Downloads (Pure)


OBJECTIVES: Total pancreatectomy (TP) is associated with significant morbidity and mortality. The severity of postoperative diabetes and existence of 'brittle diabetes' are unclear. This study sought to identify quality of life (QoL) and diabetes-specific outcomes after TP.

METHODS: Patients who underwent TP were matched for age, sex and duration of diabetes with patients with type 1 diabetes. General QoL was assessed using the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire QLQ-C30 and the PAN26 tool. Diabetes-specific outcomes were assessed using the Problem Areas in Diabetes (PAID) tool and an assessment of diabetes-specific complications and outcomes.

RESULTS: A total of 123 patients underwent TP; 88 died (none of diabetic complications) and two were lost to follow-up. Of the remaining 33 patients, 28 returned questionnaires. Fourteen general and pancreas-specific QoL measurements were all significantly worse amongst the TP cohort (QLQ-C30 + PAN26). However, when diabetes-specific outcomes were compared using the PAID tool, only one of 20 was significantly worse. HbA1c values were comparable (P = 0.299), as were diabetes-related complications such as hypoglycaemic attacks and organ dysfunction.

CONCLUSIONS: Total pancreatectomy is associated with impaired QoL on general measures compared with that in type 1 diabetes patients. Importantly, however, there was almost no significant difference in diabetes-specific outcomes as assessed by a diabetes-specific questionnaire, or in diabetes control. This study does not support the existence of 'brittle diabetes' after TP.

Original languageEnglish
Pages (from-to)814-821
Number of pages8
JournalHPB : the official journal of the International Hepato Pancreato Biliary Association
Issue number9
Publication statusPublished - Sept 2014


  • Adult
  • Biomarkers
  • Blood Glucose
  • Diabetes Mellitus
  • Diabetes Mellitus, Type 1
  • Female
  • Hemoglobin A, Glycosylated
  • Humans
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Pancreatectomy
  • Quality of Life
  • Risk Factors
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome


Dive into the research topics of 'How severe is diabetes after total pancreatectomy? A case-matched analysis'. Together they form a unique fingerprint.

Cite this