How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis?: A Comprehensive Review

Manoj Rajankunte Mahadeshwara; Maisoon Al-Jawad; Richard M. Hall; Hemant Pandit; Reem El-Gendy; Michael Bryant

doi:10.3390/bioengineering11060541

How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review

Manoj Rajankunte Mahadeshwara^*
, Maisoon Al-Jawad
, Richard M. Hall
, Hemant Pandit
, Reem El-Gendy
, Michael Bryant^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.

Original language	English
Article number	541
Number of pages	28
Journal	Bioengineering (Basel, Switzerland)
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/bioengineering11060541
Publication status	Published - 24 May 2024

Keywords

intra-articular injections
biotribology
tissue engineering
osteoarthritis treatment
cartilage lubrication

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title = "How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis?: A Comprehensive Review",

abstract = "Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.",

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T2 - A Comprehensive Review

AU - Rajankunte Mahadeshwara, Manoj

AU - Al-Jawad, Maisoon

AU - Hall, Richard M.

AU - Pandit, Hemant

AU - El-Gendy, Reem

AU - Bryant, Michael

PY - 2024/5/24

Y1 - 2024/5/24

N2 - Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.

AB - Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.

KW - intra-articular injections

KW - biotribology

KW - tissue engineering

KW - osteoarthritis treatment

KW - cartilage lubrication

U2 - 10.3390/bioengineering11060541

DO - 10.3390/bioengineering11060541

M3 - Review article

SN - 2306-5354

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JO - Bioengineering (Basel, Switzerland)

JF - Bioengineering (Basel, Switzerland)

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M1 - 541

ER -

How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review

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