TY - JOUR
T1 - How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis?
T2 - A Comprehensive Review
AU - Rajankunte Mahadeshwara, Manoj
AU - Al-Jawad, Maisoon
AU - Hall, Richard M.
AU - Pandit, Hemant
AU - El-Gendy, Reem
AU - Bryant, Michael
PY - 2024/5/24
Y1 - 2024/5/24
N2 - Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.
AB - Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.
KW - intra-articular injections
KW - biotribology
KW - tissue engineering
KW - osteoarthritis treatment
KW - cartilage lubrication
U2 - 10.3390/bioengineering11060541
DO - 10.3390/bioengineering11060541
M3 - Review article
SN - 2306-5354
VL - 11
JO - Bioengineering (Basel, Switzerland)
JF - Bioengineering (Basel, Switzerland)
IS - 6
M1 - 541
ER -