Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function

Christopher J. Kirk, Gilles Guillon, Marie Noël Balestre, Judith A. Creba, Robert H. Michell, Serge Jard

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface receptor activation to intracellular Ca2+ mobilization. Recent results indicate that the primary, receptor-mediated event in stimulated cells is a phosphodiesteric hydrolysis of phosphatidylinositol 4,5-bisphosphate to yield inositol trisphosphate and diacylglycerol. It is likely that both products of this reaction fulfill 'second messenger' roles within stimulated cells.

Original languageEnglish
Pages (from-to)1161-1167
Number of pages7
JournalBiochimie
Volume67
Issue number10-11
DOIs
Publication statusPublished - 1 Jan 1985

Keywords

  • hepatocyte
  • inositol lipid
  • vasopressin
  • WRK-1 cells

ASJC Scopus subject areas

  • Biochemistry

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