TY - JOUR
T1 - Horizontal Gene Transfers in prokaryotes show differential preferences for metabolic and translational genes
AU - Kanhere, Aditi
AU - Vingron, Martin
PY - 2009
Y1 - 2009
N2 - Horizontal gene transfer (HGT) is an important process, which contributes in bacterial pathogenesis and drug resistance. A number of methods have been proposed for detection of horizontal gene transfer. One successful approach to the detection of HGT events is due to Novichkov et al. (J. Bacteriology 186, 6575-85), who rely on comparing phylogenetic distances within a gene family with genomic distances of the source organisms. Building on their approach, we introduce outlier detection in the correlation between those two sets of distances. This approach is designed to detect horizontal transfers of core set of genes present in many bacteria. The principle behind method allows detection of xenologous gene displacements as well as acquisition of novel genes.
AB - Horizontal gene transfer (HGT) is an important process, which contributes in bacterial pathogenesis and drug resistance. A number of methods have been proposed for detection of horizontal gene transfer. One successful approach to the detection of HGT events is due to Novichkov et al. (J. Bacteriology 186, 6575-85), who rely on comparing phylogenetic distances within a gene family with genomic distances of the source organisms. Building on their approach, we introduce outlier detection in the correlation between those two sets of distances. This approach is designed to detect horizontal transfers of core set of genes present in many bacteria. The principle behind method allows detection of xenologous gene displacements as well as acquisition of novel genes.
U2 - 10.1186/1471-2148-9-9
DO - 10.1186/1471-2148-9-9
M3 - Article
C2 - 19134215
SN - 1471-2148
VL - 9
JO - BMC Evolutionary Biology
JF - BMC Evolutionary Biology
M1 - 9
ER -