Histiocytic sarcoma with interdigitating dendritic cell differentiation

DW Porter, GL Gupte, Rachel Brown, C Spary, Martin English, Jean de Ville de Goyet, Patrick McKiernan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The authors describe a rare tumor with overlapping features of true histiocytic sarcoma and interdigitating dendritic cell sarcoma occurring in infancy. A 3-month-old boy presented with hepatosplenomegaly and abdominal distention. He presented a diagnostic challenge at initial presentation despite extensive investigations. On follow-up at age 16 months he had progressive splenomegaly, thrombocytopenia, and worsening coagulopathy. A diagnosis of histiocytic sarcoma with interdigitating dendritic cell differentiation was established after an open biopsy of liver and spleen. A repeat liver biopsy coupled with splenic biopsy is recommended in young children with unexplained hepatosplenomegaly and thrombocytopenia.
Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalJ Pediatr Hematol Oncol
Volume26
Publication statusPublished - 1 Jan 2004

Fingerprint

Dive into the research topics of 'Histiocytic sarcoma with interdigitating dendritic cell differentiation'. Together they form a unique fingerprint.

Cite this