Hippocampal-Prefrontal theta oscillations support memory integration

Alexander R Backus, Simon Hanslmayr, Jan-Mathijs Schoffelen, Szabolcs Szebenyi, Christian F Doeller

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)
5152 Downloads (Pure)

Abstract

Integration of separate memories forms the basis of inferential reasoning—an essential cognitive process that enables complex behavior. Considerable evidence suggests that both hippocampus and medial prefrontal cortex (mPFC) play a crucial role in memory integration. Although previous studies indicate that theta oscillations facilitate memory processes, the electrophysiological mechanisms underlying memory integration remain elusive. To bridge this gap, we recorded magnetoencephalography data while participants performed an inference task and employed novel source reconstruction techniques to estimate oscillatory signals from the hippocampus. We found that hippocampal
theta power during encoding predicts subsequent memory integration. Moreover, we observed increased theta coherence between hippocampus and mPFC. Our results suggest that integrated memory representations arise through hippocampal theta oscillations, possibly reflecting dynamic switching between encoding and retrieval states, and facilitating communication with mPFC. These findings have important implications for our understanding of memory-based decision making and knowledge acquisition.
Original languageEnglish
Pages (from-to)450–457
JournalCurrent Biology
Volume26
Issue number4
Early online date28 Jan 2016
DOIs
Publication statusPublished - 22 Feb 2016

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