Heterogeneous profiles of coupled sleep oscillations in human hippocampus

Roy Cox, Theodor Rüber, Bernhard P Staresina, Juergen Fell

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Abstract

Cross-frequency coupling of sleep oscillations is thought to mediate memory consolidation. While the hippocampus is deemed central to this process, detailed knowledge of which oscillatory rhythms interact in the sleeping human hippocampus is lacking. Combining intracranial hippocampal and non-invasive electroencephalography from twelve neurosurgical patients, we characterized spectral power and coupling during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Hippocampal coupling was extensive, with the majority of channels expressing spectral interactions. NREM consistently showed delta-ripple coupling, but ripples were also modulated by slow oscillations (SOs) and sleep spindles. SO-delta and SO-theta coupling, as well as interactions between delta/theta and spindle/beta frequencies also occurred. During REM, limited interactions between delta/theta and beta frequencies emerged. Moreover, oscillatory organization differed substantially between i) hippocampus and scalp, ii) sites along the anterior-posterior hippocampal axis, and iii) individuals. Overall, these results extend and refine our understanding of hippocampal sleep oscillations.

Original languageEnglish
Article number116178
JournalNeuroImage
Volume202
Early online date7 Sep 2019
DOIs
Publication statusPublished - 15 Nov 2019

Keywords

  • Cross-frequency coupling
  • Electrophysiology
  • Hippocampus
  • Individual differences
  • Sleep

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