Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

Philippe Chouteau; Nicole Defer; Alexandre Florimond; Julien Caldéraro; Martin Higgs; Aurore Gaudin; Emilie Mérour; Daniel Dhumeaux; Hervé Lerat; Jean-Michel Pawlotsky

doi:10.1016/j.jhep.2012.04.019

Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

Philippe Chouteau, Nicole Defer, Alexandre Florimond, Julien Caldéraro, Martin Higgs, Aurore Gaudin, Emilie Mérour, Daniel Dhumeaux, Hervé Lerat, Jean-Michel Pawlotsky

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

During chronic HCV infection, activation of fibrogenesis appears to be principally related to local inflammation. However, the direct role of hepatic HCV protein expression in fibrogenesis remains unknown.

Original language	English
Pages (from-to)	499-507
Number of pages	9
Journal	International journal of hepatology
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/j.jhep.2012.04.019
Publication status	Published - Sept 2012

Bibliographical note

Keywords

Animals
Bile Ducts
Carbon Tetrachloride
Cell Proliferation
Chemokine CCL5
Extracellular Matrix
Gene Expression
Hepacivirus
Hepatitis C, Chronic
Hepatocytes
Keratin-19
Liver Cirrhosis
Matrix Metalloproteinase 13
Matrix Metalloproteinase 3
Matrix Metalloproteinase 7
Mice
Mice, Transgenic
Open Reading Frames
RNA, Messenger
Reactive Oxygen Species
Stem Cells
Tissue Inhibitor of Metalloproteinase-1
Viral Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhep.2012.04.019

Cite this

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title = "Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent",

abstract = "During chronic HCV infection, activation of fibrogenesis appears to be principally related to local inflammation. However, the direct role of hepatic HCV protein expression in fibrogenesis remains unknown.",

keywords = "Animals, Bile Ducts, Carbon Tetrachloride, Cell Proliferation, Chemokine CCL5, Extracellular Matrix, Gene Expression, Hepacivirus, Hepatitis C, Chronic, Hepatocytes, Keratin-19, Liver Cirrhosis, Matrix Metalloproteinase 13, Matrix Metalloproteinase 3, Matrix Metalloproteinase 7, Mice, Mice, Transgenic, Open Reading Frames, RNA, Messenger, Reactive Oxygen Species, Stem Cells, Tissue Inhibitor of Metalloproteinase-1, Viral Proteins",

author = "Philippe Chouteau and Nicole Defer and Alexandre Florimond and Julien Cald{\'e}raro and Martin Higgs and Aurore Gaudin and Emilie M{\'e}rour and Daniel Dhumeaux and Herv{\'e} Lerat and Jean-Michel Pawlotsky",

year = "2012",

month = sep,

doi = "10.1016/j.jhep.2012.04.019",

language = "English",

volume = "57",

pages = "499--507",

journal = "International journal of hepatology",

issn = "2090-3448",

publisher = "Hindawi Publishing Corporation",

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TY - JOUR

T1 - Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

AU - Chouteau, Philippe

AU - Defer, Nicole

AU - Florimond, Alexandre

AU - Caldéraro, Julien

AU - Higgs, Martin

AU - Gaudin, Aurore

AU - Mérour, Emilie

AU - Dhumeaux, Daniel

AU - Lerat, Hervé

AU - Pawlotsky, Jean-Michel

PY - 2012/9

Y1 - 2012/9

N2 - During chronic HCV infection, activation of fibrogenesis appears to be principally related to local inflammation. However, the direct role of hepatic HCV protein expression in fibrogenesis remains unknown.

AB - During chronic HCV infection, activation of fibrogenesis appears to be principally related to local inflammation. However, the direct role of hepatic HCV protein expression in fibrogenesis remains unknown.

KW - Animals

KW - Bile Ducts

KW - Carbon Tetrachloride

KW - Cell Proliferation

KW - Chemokine CCL5

KW - Extracellular Matrix

KW - Gene Expression

KW - Hepacivirus

KW - Hepatitis C, Chronic

KW - Hepatocytes

KW - Keratin-19

KW - Liver Cirrhosis

KW - Matrix Metalloproteinase 13

KW - Matrix Metalloproteinase 3

KW - Matrix Metalloproteinase 7

KW - Mice

KW - Mice, Transgenic

KW - Open Reading Frames

KW - RNA, Messenger

KW - Reactive Oxygen Species

KW - Stem Cells

KW - Tissue Inhibitor of Metalloproteinase-1

KW - Viral Proteins

U2 - 10.1016/j.jhep.2012.04.019

DO - 10.1016/j.jhep.2012.04.019

M3 - Article

C2 - 22613003

SN - 2090-3448

VL - 57

SP - 499

EP - 507

JO - International journal of hepatology

JF - International journal of hepatology

IS - 3

ER -

Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

Abstract

Bibliographical note

Keywords

UN SDGs

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