Hepatitis C virus entry and the tetraspanin CD81.

Michelle Farquhar, Helen Harris, Jane McKeating

Research output: Contribution to journalArticle

33 Citations (Scopus)


CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.
Original languageEnglish
Pages (from-to)532-6
Number of pages5
JournalBiochemical Society Transactions
Issue number2
Publication statusPublished - 1 Apr 2011


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