Hepatitis C virus entry and the tetraspanin CD81.

Michelle Farquhar; Helen Harris; Jane McKeating

doi:10.1042/BST0390532

Hepatitis C virus entry and the tetraspanin CD81.

Michelle Farquhar, Helen Harris, Jane McKeating

Immunology and Immunotherapy

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.

Original language	English
Pages (from-to)	532-6
Number of pages	5
Journal	Biochemical Society Transactions
Volume	39
Issue number	2
DOIs	https://doi.org/10.1042/BST0390532
Publication status	Published - 1 Apr 2011

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10.1042/BST0390532

The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis
McKeating, J.
Medical Research Council
1/01/12 → 30/06/17
Project: Research Councils
Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury
McKeating, J. & Balfe, P.
Medical Research Council
1/10/09 → 30/09/12
Project: Research Councils

Cite this

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title = "Hepatitis C virus entry and the tetraspanin CD81.",

abstract = "CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.",

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AB - CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.

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Hepatitis C virus entry and the tetraspanin CD81.

Abstract

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The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis

Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury

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