Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria

Guillemette Fouquet; Kym Ie Snell; Stéphanie Guidez; Susanna Schraen; Eileen Boyle; Loïc Renaud; Déborah Desmier; Antoine Machet; Niels Moya; Thomas Systchenko; Cécile Gruchet; Olivier Decaux; Bertrand Arnulf; Cécile Fohrer; Valentine Richez; Brigitte Kolb; Margaret Macro; Lionel Karlin; Bruno Royer; Brigitte Pegourie; Benjamin Hebraud; Denis Caillot; Aurore Perrot; Philippe Moreau; Thierry Facon; Hervé Avet-Loiseau; Thomas Dejoie; Cyrille Hulin; Stephen Harding; Xavier Leleu

doi:10.1080/10428194.2017.1339876

Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria

Guillemette Fouquet, Kym Ie Snell, Stéphanie Guidez, Susanna Schraen, Eileen Boyle, Loïc Renaud, Déborah Desmier, Antoine Machet, Niels Moya, Thomas Systchenko, Cécile Gruchet, Olivier Decaux, Bertrand Arnulf, Cécile Fohrer, Valentine Richez, Brigitte Kolb, Margaret Macro, Lionel Karlin, Bruno Royer, Brigitte PegourieBenjamin Hebraud, Denis Caillot, Aurore Perrot, Philippe Moreau, Thierry Facon, Hervé Avet-Loiseau, Thomas Dejoie, Cyrille Hulin, Stephen Harding, Xavier Leleu

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Automated serum heavy + light chain (HLC) immunoassays can measure the intact immunoglobulins of each light chain type separately. We though to compare HLC assays with electrophoretic techniques in determining International Myeloma Working Group (IMWG) response criteria. 114 myeloma patients from 2 trials were included. HLC measurements were made utilizing archived sera and response assessments compared with those based on electrophoretic analysis at the time of the trials. Assessments at ∼90 days and maximal response were compared as was the power of the 2 techniques for predicting later responses, overall survival, and progression. The kappa statistic indicated good agreement between the 2 methods for determining IMWG response criteria, although HLC measurements might give better predictions of subsequent responses and frequently gave an earlier indication of change. HLC measurements could represent an alternative to electrophoretic techniques in determining IMWG response. Validation with a greater range of patient responses is needed for confirmation.

Original language	English
Pages (from-to)	583-589
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	59
Issue number	3
DOIs	https://doi.org/10.1080/10428194.2017.1339876
Publication status	Published - Mar 2018

Keywords

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor/blood
Female
Follow-Up Studies
Humans
Immunoassay/standards
Immunoglobulin Heavy Chains/blood
Immunoglobulin Light Chains/blood
Male
Middle Aged
Monitoring, Immunologic/methods
Multiple Myeloma/blood
Prognosis
Remission Induction
Survival Rate

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Fouquet, G., Snell, K. I., Guidez, S., Schraen, S., Boyle, E., Renaud, L., Desmier, D., Machet, A., Moya, N., Systchenko, T., Gruchet, C., Decaux, O., Arnulf, B., Fohrer, C., Richez, V., Kolb, B., Macro, M., Karlin, L., Royer, B., ... Leleu, X. (2018). Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria. Leukemia and Lymphoma, 59(3), 583-589. https://doi.org/10.1080/10428194.2017.1339876

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title = "Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria",

abstract = "Automated serum heavy + light chain (HLC) immunoassays can measure the intact immunoglobulins of each light chain type separately. We though to compare HLC assays with electrophoretic techniques in determining International Myeloma Working Group (IMWG) response criteria. 114 myeloma patients from 2 trials were included. HLC measurements were made utilizing archived sera and response assessments compared with those based on electrophoretic analysis at the time of the trials. Assessments at ∼90 days and maximal response were compared as was the power of the 2 techniques for predicting later responses, overall survival, and progression. The kappa statistic indicated good agreement between the 2 methods for determining IMWG response criteria, although HLC measurements might give better predictions of subsequent responses and frequently gave an earlier indication of change. HLC measurements could represent an alternative to electrophoretic techniques in determining IMWG response. Validation with a greater range of patient responses is needed for confirmation.",

keywords = "Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/blood, Female, Follow-Up Studies, Humans, Immunoassay/standards, Immunoglobulin Heavy Chains/blood, Immunoglobulin Light Chains/blood, Male, Middle Aged, Monitoring, Immunologic/methods, Multiple Myeloma/blood, Prognosis, Remission Induction, Survival Rate",

author = "Guillemette Fouquet and Snell, {Kym Ie} and St{\'e}phanie Guidez and Susanna Schraen and Eileen Boyle and Lo{\"i}c Renaud and D{\'e}borah Desmier and Antoine Machet and Niels Moya and Thomas Systchenko and C{\'e}cile Gruchet and Olivier Decaux and Bertrand Arnulf and C{\'e}cile Fohrer and Valentine Richez and Brigitte Kolb and Margaret Macro and Lionel Karlin and Bruno Royer and Brigitte Pegourie and Benjamin Hebraud and Denis Caillot and Aurore Perrot and Philippe Moreau and Thierry Facon and Herv{\'e} Avet-Loiseau and Thomas Dejoie and Cyrille Hulin and Stephen Harding and Xavier Leleu",

year = "2018",

month = mar,

doi = "10.1080/10428194.2017.1339876",

language = "English",

volume = "59",

pages = "583--589",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Taylor & Francis",

number = "3",

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Fouquet, G, Snell, KI, Guidez, S, Schraen, S, Boyle, E, Renaud, L, Desmier, D, Machet, A, Moya, N, Systchenko, T, Gruchet, C, Decaux, O, Arnulf, B, Fohrer, C, Richez, V, Kolb, B, Macro, M, Karlin, L, Royer, B, Pegourie, B, Hebraud, B, Caillot, D, Perrot, A, Moreau, P, Facon, T, Avet-Loiseau, H, Dejoie, T, Hulin, C, Harding, S & Leleu, X 2018, 'Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria', Leukemia and Lymphoma, vol. 59, no. 3, pp. 583-589. https://doi.org/10.1080/10428194.2017.1339876

TY - JOUR

T1 - Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria

AU - Fouquet, Guillemette

AU - Snell, Kym Ie

AU - Guidez, Stéphanie

AU - Schraen, Susanna

AU - Boyle, Eileen

AU - Renaud, Loïc

AU - Desmier, Déborah

AU - Machet, Antoine

AU - Moya, Niels

AU - Systchenko, Thomas

AU - Gruchet, Cécile

AU - Decaux, Olivier

AU - Arnulf, Bertrand

AU - Fohrer, Cécile

AU - Richez, Valentine

AU - Kolb, Brigitte

AU - Macro, Margaret

AU - Karlin, Lionel

AU - Royer, Bruno

AU - Pegourie, Brigitte

AU - Hebraud, Benjamin

AU - Caillot, Denis

AU - Perrot, Aurore

AU - Moreau, Philippe

AU - Facon, Thierry

AU - Avet-Loiseau, Hervé

AU - Dejoie, Thomas

AU - Hulin, Cyrille

AU - Harding, Stephen

AU - Leleu, Xavier

PY - 2018/3

Y1 - 2018/3

N2 - Automated serum heavy + light chain (HLC) immunoassays can measure the intact immunoglobulins of each light chain type separately. We though to compare HLC assays with electrophoretic techniques in determining International Myeloma Working Group (IMWG) response criteria. 114 myeloma patients from 2 trials were included. HLC measurements were made utilizing archived sera and response assessments compared with those based on electrophoretic analysis at the time of the trials. Assessments at ∼90 days and maximal response were compared as was the power of the 2 techniques for predicting later responses, overall survival, and progression. The kappa statistic indicated good agreement between the 2 methods for determining IMWG response criteria, although HLC measurements might give better predictions of subsequent responses and frequently gave an earlier indication of change. HLC measurements could represent an alternative to electrophoretic techniques in determining IMWG response. Validation with a greater range of patient responses is needed for confirmation.

AB - Automated serum heavy + light chain (HLC) immunoassays can measure the intact immunoglobulins of each light chain type separately. We though to compare HLC assays with electrophoretic techniques in determining International Myeloma Working Group (IMWG) response criteria. 114 myeloma patients from 2 trials were included. HLC measurements were made utilizing archived sera and response assessments compared with those based on electrophoretic analysis at the time of the trials. Assessments at ∼90 days and maximal response were compared as was the power of the 2 techniques for predicting later responses, overall survival, and progression. The kappa statistic indicated good agreement between the 2 methods for determining IMWG response criteria, although HLC measurements might give better predictions of subsequent responses and frequently gave an earlier indication of change. HLC measurements could represent an alternative to electrophoretic techniques in determining IMWG response. Validation with a greater range of patient responses is needed for confirmation.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers, Tumor/blood

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunoassay/standards

KW - Immunoglobulin Heavy Chains/blood

KW - Immunoglobulin Light Chains/blood

KW - Male

KW - Middle Aged

KW - Monitoring, Immunologic/methods

KW - Multiple Myeloma/blood

KW - Prognosis

KW - Remission Induction

KW - Survival Rate

U2 - 10.1080/10428194.2017.1339876

DO - 10.1080/10428194.2017.1339876

M3 - Article

C2 - 28697637

SN - 1042-8194

VL - 59

SP - 583

EP - 589

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 3

ER -

Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria

Abstract

Keywords

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