TY - JOUR
T1 - Health status of adult survivors of childhood cancer: a large population-based study from the British Childhood Cancer Survivor study
AU - Reulen, Raoul
AU - Hawkins, Michael
AU - Winter, David
AU - Lancashire, Emma
AU - Zeegers, Maurice
AU - Jenney, ME
AU - Salters, SJ
AU - Jenkinson, C
PY - 2007/8/1
Y1 - 2007/8/1
N2 - The purpose of this study was to investigate the effect of childhood cancer and its treatment on self-reported health-status in 10,189 adult survivors of childhood cancer in Britain. Age- and sex-adjusted scores on the SF-36 Mental and Physical Component Summary scales (MCS, PCS, respectively) were compared between survivors and UK norms, and between subgroups of survivors, by multiple regression. Survivors had comparable scores to UK-norms on the MCS scale (difference (D) = -0.1, 99% CI: -0.5, 0.3). The difference in scores between survivors and UK-norms on the PCS scale varied by age (p(heterogeneity) <0.001). Young survivors (16-19 years) scored similarly to UK-norms (D = 0.5, (-1.1, 2.2), whereas the age groups of 25 and older scored statistically and clinically significantly below UK-norms (all p-values <0.0001), with Ds ranging between -2.3 (-3.5, -1.2) and -3.7 (-5.0, -2.4). Survivors of central nervous system (CNS) and bone tumors scored significantly (p-value at all ages
AB - The purpose of this study was to investigate the effect of childhood cancer and its treatment on self-reported health-status in 10,189 adult survivors of childhood cancer in Britain. Age- and sex-adjusted scores on the SF-36 Mental and Physical Component Summary scales (MCS, PCS, respectively) were compared between survivors and UK norms, and between subgroups of survivors, by multiple regression. Survivors had comparable scores to UK-norms on the MCS scale (difference (D) = -0.1, 99% CI: -0.5, 0.3). The difference in scores between survivors and UK-norms on the PCS scale varied by age (p(heterogeneity) <0.001). Young survivors (16-19 years) scored similarly to UK-norms (D = 0.5, (-1.1, 2.2), whereas the age groups of 25 and older scored statistically and clinically significantly below UK-norms (all p-values <0.0001), with Ds ranging between -2.3 (-3.5, -1.2) and -3.7 (-5.0, -2.4). Survivors of central nervous system (CNS) and bone tumors scored significantly (p-value at all ages
KW - childhood cancer survivors
KW - SF-36
KW - epidemiology
KW - health-status
U2 - 10.1002/ijc.22658
DO - 10.1002/ijc.22658
M3 - Article
C2 - 17405119
SN - 0020-7136
VL - 121
SP - 633
EP - 640
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -
