Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

Yu Feng; Li Wei; Shichao Zhu; Fu Qiao; Xiaoxia Zhang; Yan Kang; Lin Cai; Mei Kang; Alan McNally; Zhiyong Zong

doi:10.1016/j.jhin.2019.10.006

Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

Yu Feng, Li Wei, Shichao Zhu, Fu Qiao, Xiaoxia Zhang, Yan Kang, Lin Cai, Mei Kang, Alan McNally, Zhiyong Zong

Microbes, Infections and Microbiomes

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla _NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission.

Original language	English
Journal	The Journal of Hospital Infection
Early online date	10 Oct 2019
DOIs	https://doi.org/10.1016/j.jhin.2019.10.006
Publication status	E-pub ahead of print - 10 Oct 2019

Bibliographical note

Keywords

sinks
carbapenemases
carbapenem resistance
Klebsiella pneumoniae

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https://www.sciencedirect.com/science/article/pii/S0195670119304384Licence: None: All rights reserved

Cite this

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title = "Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU",

abstract = "Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission. ",

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T1 - Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

AU - Feng, Yu

AU - Wei, Li

AU - Zhu, Shichao

AU - Qiao, Fu

AU - Zhang, Xiaoxia

AU - Kang, Yan

AU - Cai, Lin

AU - Kang, Mei

AU - McNally, Alan

AU - Zong, Zhiyong

PY - 2019/10/10

Y1 - 2019/10/10

N2 - Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission.

AB - Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates (carrying the carbapenemase gene bla NDM-5) of sequence type 16 caused hospital-acquired bloodstream infection or gut colonization in two patients in an intensive care unit (ICU). It was hypothesized that handwashing sinks were the source, and all handwashing sinks in the ICU were sampled. Whole-genome sequencing and analysis revealed that one sink was the source of CRKP colonization/infection in both patients, instead of direct transmission of a common clone between the patients. This study highlights handwashing sinks as an important source of multi-drug-resistant organisms. Sink management, including prohibition of disposal of body fluids and daily disinfection with chlorine, curbed the transmission.

KW - sinks

KW - carbapenemases

KW - carbapenem resistance

KW - Klebsiella pneumoniae

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DO - 10.1016/j.jhin.2019.10.006

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JF - The Journal of Hospital Infection

ER -

Handwashing sinks as the source of transmission of ST16 carbapenem-resistant Klebsiella pneumoniae, an international high-risk clone, in ICU

Abstract

Bibliographical note

Keywords

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