Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

Ebrahim Rajab; Michael B. Keogh; Ashang L. Laiva; Fatima Al Hannan; Maryam Fateel; Fatema Abdulwahab; Fatema Al Madhoob; Bassam AlHamer; Samar Y. Ghazzal; Abdulla Dawaishan; Sadiq Mahdi; Abdulrahman Qareeballa; Sayed M. Almosawi; Faisal Falamarzi; Khalifa ElMusharaf; Amer Kamal

doi:10.1016/j.jff.2021.104757

Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

Ebrahim Rajab^*, Michael B. Keogh, Ashang L. Laiva, Fatima Al Hannan, Maryam Fateel, Fatema Abdulwahab, Fatema Al Madhoob, Bassam AlHamer, Samar Y. Ghazzal, Abdulla Dawaishan, Sadiq Mahdi, Abdulrahman Qareeballa, Sayed M. Almosawi, Faisal Falamarzi, Khalifa ElMusharaf, Amer Kamal

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.

Original language	English
Article number	104757
Number of pages	9
Journal	Journal of Functional Foods
Volume	87
Early online date	16 Sept 2021
DOIs	https://doi.org/10.1016/j.jff.2021.104757
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
This project was funded by a joint grant from the Arabian Gulf University and Royal college of Surgeons in Ireland- Medical University Bahrain [Grant number – Not applicable].

Publisher Copyright:
© 2021 The Authors

Keywords

Diabetes
Gum Arabic
Hippocampus
Memory
Mitochondria

ASJC Scopus subject areas

Medicine (miscellaneous)
Food Science
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Rajab, E., Keogh, M. B., Laiva, A. L., Al Hannan, F., Fateel, M., Abdulwahab, F., Al Madhoob, F., AlHamer, B., Ghazzal, S. Y., Dawaishan, A., Mahdi, S., Qareeballa, A., Almosawi, S. M., Falamarzi, F., ElMusharaf, K., & Kamal, A. (2021). Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats. Journal of Functional Foods, 87, Article 104757. https://doi.org/10.1016/j.jff.2021.104757

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title = "Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats",

abstract = "The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.",

keywords = "Diabetes, Gum Arabic, Hippocampus, Memory, Mitochondria",

author = "Ebrahim Rajab and Keogh, {Michael B.} and Laiva, {Ashang L.} and {Al Hannan}, Fatima and Maryam Fateel and Fatema Abdulwahab and {Al Madhoob}, Fatema and Bassam AlHamer and Ghazzal, {Samar Y.} and Abdulla Dawaishan and Sadiq Mahdi and Abdulrahman Qareeballa and Almosawi, {Sayed M.} and Faisal Falamarzi and Khalifa ElMusharaf and Amer Kamal",

note = "Funding Information: This project was funded by a joint grant from the Arabian Gulf University and Royal college of Surgeons in Ireland- Medical University Bahrain [Grant number – Not applicable]. Publisher Copyright: {\textcopyright} 2021 The Authors",

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doi = "10.1016/j.jff.2021.104757",

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Rajab, E, Keogh, MB, Laiva, AL, Al Hannan, F, Fateel, M, Abdulwahab, F, Al Madhoob, F, AlHamer, B, Ghazzal, SY, Dawaishan, A, Mahdi, S, Qareeballa, A, Almosawi, SM, Falamarzi, F, ElMusharaf, K & Kamal, A 2021, 'Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats', Journal of Functional Foods, vol. 87, 104757. https://doi.org/10.1016/j.jff.2021.104757

TY - JOUR

T1 - Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

AU - Rajab, Ebrahim

AU - Keogh, Michael B.

AU - Laiva, Ashang L.

AU - Al Hannan, Fatima

AU - Fateel, Maryam

AU - Abdulwahab, Fatema

AU - Al Madhoob, Fatema

AU - AlHamer, Bassam

AU - Ghazzal, Samar Y.

AU - Dawaishan, Abdulla

AU - Mahdi, Sadiq

AU - Qareeballa, Abdulrahman

AU - Almosawi, Sayed M.

AU - Falamarzi, Faisal

AU - ElMusharaf, Khalifa

AU - Kamal, Amer

N1 - Funding Information: This project was funded by a joint grant from the Arabian Gulf University and Royal college of Surgeons in Ireland- Medical University Bahrain [Grant number – Not applicable]. Publisher Copyright: © 2021 The Authors

PY - 2021/12

Y1 - 2021/12

N2 - The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.

AB - The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.

KW - Diabetes

KW - Gum Arabic

KW - Hippocampus

KW - Memory

KW - Mitochondria

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DO - 10.1016/j.jff.2021.104757

M3 - Article

AN - SCOPUS:85114987541

SN - 1756-4646

VL - 87

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 104757

ER -

Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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