Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD.
|Number of pages||6|
|Journal||Developmental Cognitive Neuroscience|
|Early online date||11 Jun 2015|
|Publication status||Published - Aug 2015|
Bibliographical noteCopyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
- Attention deficit/hyperactivity disorder (ADHD)
- Anterior cingulate cortex
- Emotion regulation