Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study

Thomas Villemonteix; Stéphane A De Brito; Hichem Slama; Martin Kavec; Danielle Balériaux; Thierry Metens; Simon Baijot; Alison Mary; Philippe Peigneux; Isabelle Massat

doi:10.1016/j.dcn.2015.06.001

Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study

Thomas Villemonteix, Stéphane A De Brito, Hichem Slama, Martin Kavec, Danielle Balériaux, Thierry Metens, Simon Baijot, Alison Mary, Philippe Peigneux, Isabelle Massat

Psychology

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16 Citations (Scopus)

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Abstract

Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD.

Original language	English
Pages (from-to)	32-7
Number of pages	6
Journal	Developmental Cognitive Neuroscience
Volume	14
Early online date	11 Jun 2015
DOIs	https://doi.org/10.1016/j.dcn.2015.06.001
Publication status	Published - Aug 2015

Bibliographical note

Keywords

Attention deficit/hyperactivity disorder (ADHD)
Anterior cingulate cortex
Gender
MRI
Emotion regulation

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10.1016/j.dcn.2015.06.001

Villemonteix_et_al_Grey_matter_volume_differences_Developmental_Cognitive_Neuroscience_2015
Checked October 2015
Final published version, 691 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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Villemonteix, T., De Brito, S. A., Slama, H., Kavec, M., Balériaux, D., Metens, T., Baijot, S., Mary, A., Peigneux, P., & Massat, I. (2015). Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study. Developmental Cognitive Neuroscience, 14, 32-7. Advance online publication. https://doi.org/10.1016/j.dcn.2015.06.001

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abstract = "Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD.",

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Villemonteix, T, De Brito, SA, Slama, H, Kavec, M, Balériaux, D, Metens, T, Baijot, S, Mary, A, Peigneux, P & Massat, I 2015, 'Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study', Developmental Cognitive Neuroscience, vol. 14, pp. 32-7. https://doi.org/10.1016/j.dcn.2015.06.001

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T2 - A voxel-based morphometry study

AU - Villemonteix, Thomas

AU - De Brito, Stéphane A

AU - Slama, Hichem

AU - Kavec, Martin

AU - Balériaux, Danielle

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AU - Baijot, Simon

AU - Mary, Alison

AU - Peigneux, Philippe

AU - Massat, Isabelle

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AB - Female participants have been underrepresented in previous structural magnetic resonance imaging reports on attention-deficit/hyperactivity disorder (ADHD). In this study, we used optimized voxel-based morphometry to examine grey matter volumes in a sample of 33 never-medicated children with combined-type ADHD and 27 typically developing (TD) children. We found a gender-by-diagnosis interaction effect in the ventral anterior cingulate cortex (ACC), whereby boys with ADHD exhibited reduced volumes compared with TD boys, while girls with ADHD showed increased volumes when compared with TD girls. Considering the key role played by the ventral ACC in emotional regulation, we discuss the potential contribution of these alterations to gender-specific symptoms' profiles in ADHD.

KW - Attention deficit/hyperactivity disorder (ADHD)

KW - Anterior cingulate cortex

KW - Gender

KW - MRI

KW - Emotion regulation

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DO - 10.1016/j.dcn.2015.06.001

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SN - 1878-9293

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JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

ER -

Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: A voxel-based morphometry study

Abstract

Bibliographical note

Keywords

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