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Granzyme K activates the entire complement cascade
Carlos A. Donada
, Erin Theisen
, Fan Zhang
, Aparna Nathan
, Madison L. Fairfield
, Karishma Vijay Rupani
, Dominique Jones
, Kellsey P. Johannes
, Accelerating Medicines Partnership RA/SLE Network
, Soumya Raychaudhuri
, Daniel F. Dwyer
, A. Helena Jonsson
, Michael B. Brenner
*
*
Corresponding author for this work
Inflammation and Ageing
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peer-review
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Keyphrases
Complement Cascade
100%
Granzyme K
100%
Complement Activation
62%
Rheumatoid Arthritis
25%
CD8+ T Cells
25%
Synovium
25%
Granzyme
25%
T Cells
12%
Arthritis
12%
Tumor Cells
12%
Fibroblasts
12%
Cell Death
12%
Lymphocytes
12%
Gene-deficient Mice
12%
Infected Cells
12%
Protease
12%
Chronic Inflammatory Diseases
12%
Inflammation
12%
Serine Protease
12%
Dermatitis
12%
Effector Molecules
12%
Natural Killer
12%
Cell-like
12%
Tissue Inflammation
12%
C3 Convertase
12%
Primary Function
12%
C5 Convertase
12%
Innate-like
12%
Multiple Diseases
12%
Membrane Attack Complex
12%
Tryptase
12%
Opsonin
12%
Complement Proteins
12%
Anaphylatoxin C5a
12%
Convertase
12%
Anaphylatoxin C3a
12%
Immunology and Microbiology
Granzyme
100%
Complement Activation
50%
Inflammatory Arthritis
20%
Cytotoxic T-Cell
20%
Synovium
20%
Complement Component C4b
20%
T Cell
10%
Tumor Cell
10%
Fibroblast
10%
Inflammatory Disorder
10%
Cell Death
10%
Lymphocyte
10%
Dermatitis
10%
Natural Killer Cell
10%
Arthritis
10%
Comorbidity
10%
C3b
10%
C3-Convertase
10%
C5-Convertase
10%
Complement Membrane Attack Complex
10%
Complement Component 5a
10%
Opsonin
10%
Anaphylatoxin
10%
Serine
10%