GPVI and CLEC-2

Elizabeth J. Haining, Phillip L.R. Nicolson, Marie Blanche Onselaer, Natalie S. Poulter, Julie Rayes, Mark R. Thomas, Steve P. Watson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM). This chapter discusses what is known about the structure, ligands, and signaling of both proteins, and the diverse and complex platelet functions that they mediate.

Original languageEnglish
Title of host publicationPlatelets
PublisherElsevier Masson
Pages213-226
Number of pages14
ISBN (Electronic)9780128134566
DOIs
Publication statusPublished - 1 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • CLEC-2
  • Collagen
  • GPVI
  • HemITAM
  • Hemostasis
  • Inflammation
  • Lymphangiogenesis
  • Podoplanin
  • Thrombosis
  • Vascular integrity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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