Projects per year
Abstract
The regenerative response of ensheating glia to central nervous system (CNS) injury involves proliferation and differentiation, axonal re-enwrapment and some recovery of behaviour. Understanding this limited response could enable the enhancement of it. In Drosophila, the glial progenitor state is maintained by Notch, an activator of cell division and Prospero (Pros), a repressor. Injury provokes the activation of NFκB and up-regulation of Kon-tiki (Kon), driving cell proliferation. Homeostatic switch-off comes about as two negative feedback loops involving Pros terminate the response. Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia. Controlling these genes is key for therapeutic manipulation of progenitors and stem cells to promote regeneration of the damaged CNS.
Original language | English |
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Pages (from-to) | 182-187 |
Number of pages | 6 |
Journal | Current Opinion in Neurobiology |
Volume | 47 |
Early online date | 7 Nov 2017 |
DOIs | |
Publication status | Published - Dec 2017 |
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Dive into the research topics of 'Go and stop signals for glial regeneration'. Together they form a unique fingerprint.Projects
- 4 Finished
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The genetic mechanisms underlying the regenerative potential of ensheathing glial cells in Drosophila
Biotechnology & Biological Sciences Research Council
1/05/14 → 31/10/17
Project: Research Councils
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BBSRC ISIS - The molecular control of glial progenitor proliferation in Drosophila and mammals: investigation of Prox1 conditional knock-out mutant mice
Hidalgo, A. & Logan, A.
Biotechnology & Biological Sciences Research Council
1/03/13 → 30/04/13
Project: Research Councils
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Development of a Small Molecule Combinatorial Treatment for RGC Survival and Axon Regeneration to Restore Sight After Optic Neuropathy
Logan, A. & Morgan-Warren, P.
1/09/12 → 31/08/15
Project: Research Councils
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The molecular control of glial progenitor proliferation in Drosophila and mammals
Hidalgo, A. & Logan, A.
Biotechnology & Biological Sciences Research Council
4/01/10 → 30/06/13
Project: Research Councils