Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

Kesar Jagdev; Damiano Tanini; Jack W Lownes; Carlotta Figliola; Louise Male; Antonella Capperucci; Richard S Grainger

doi:10.1039/d1ob02153b

Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

Kesar Jagdev, Damiano Tanini, Jack W Lownes, Carlotta Figliola, Louise Male, Antonella Capperucci, Richard S Grainger

Chemistry

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Abstract

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

Original language	English
Pages (from-to)	10565-10569
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	48
Early online date	30 Nov 2021
DOIs	https://doi.org/10.1039/d1ob02153b
Publication status	E-pub ahead of print - 30 Nov 2021

Keywords

Biochemistry
Organic Chemistry
Physical and Theoretical Chemistry

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10.1039/d1ob02153bLicence: Creative Commons: Attribution (CC BY)

JagdevK2021GlutathioneFinal published version, 842 KBLicence: Creative Commons: Attribution (CC BY)

Chemistry at Birmingham: a Response to the EPSRC Call: Core Capability for Chemistry Research
Simpkins, N. (Principal Investigator), Anderson, P. (Co-Investigator), Britton, M. (Co-Investigator), Bunch, J. (Co-Investigator), Preece, J. (Co-Investigator) & Slater, P. (Co-Investigator)
Engineering & Physical Science Research Council
1/01/13 → 31/03/13
Project: Research

Cite this

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title = "Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides",

abstract = "Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.",

keywords = "Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry",

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AU - Jagdev, Kesar

AU - Tanini, Damiano

AU - Lownes, Jack W

AU - Figliola, Carlotta

AU - Male, Louise

AU - Capperucci, Antonella

AU - Grainger, Richard S

PY - 2021/11/30

Y1 - 2021/11/30

N2 - Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

AB - Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

KW - Biochemistry

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

U2 - 10.1039/d1ob02153b

DO - 10.1039/d1ob02153b

M3 - Article

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SN - 1477-0520

VL - 19

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 48

ER -

Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

Abstract

Keywords

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Projects

Chemistry at Birmingham: a Response to the EPSRC Call: Core Capability for Chemistry Research

Cite this