Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

Kesar Jagdev, Damiano Tanini, Jack W Lownes, Carlotta Figliola, Louise Male, Antonella Capperucci, Richard S Grainger

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Abstract

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

Original languageEnglish
JournalOrganic and Biomolecular Chemistry
Early online date30 Nov 2021
DOIs
Publication statusE-pub ahead of print - 30 Nov 2021

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