Glucosamine but not iboprofen alters cartilage turnover in osteoarthritis patients in response to physical training

S.G. Petersen, T Saxne, D Heinegard, M Hansen, Lars Holm, S Koskinen, C Stordal, H. Christensen, P. Aagaard, Michael Kjær

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46 Citations (Scopus)

Abstract

OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo. DESIGN: A 12-week double blind, placebo controlled, randomized study. METHOD: Thirty-six elderly patients with bilateral tibiofemoral knee OA determined by radiography were randomly assigned to treatment with glucosamine (n=12), ibuprofen (n=12) or placebo (n=12) during 12 weeks of strength training of both legs with focus on the quadriceps muscle. Strength tests (5 repetition maximum), blood and urine sampling were performed before and after the training period. Serum COMP and urinary CTX-II were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: All three groups increased their muscle strength following 12 weeks of strength training (P
Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalOsteoarthritis and Cartilage
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2010

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