Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia

Ts Han, Rh Stimson, DA Rees, N Krone, Ds Willis, Gs Conway, W Arlt, Br Walker, Rj Ross, The United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

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    39 Citations (Scopus)


    BACKGROUND: Adults with congenital adrenal hyperplasia (CAH) are treated with a wide variety of glucocorticoid treatment regimens. OBJECTIVE, DESIGN AND METHODS: To test whether drug dose and timing of glucocorticoid treatment regimen impacts on health outcomes. This was a cross-sectional study of 196 adult CAH patients in whom treatment and health outcomes were measured. Glucocorticoid dose was converted to prednisolone dose equivalent (PreDEq) using three published formulae. Associations between the type of glucocorticoid regimen or PreDEq with specific health outcome variables were tested using partial correlation and principal components analysis (PCA). RESULTS: Patients on dexamethasone had lower androgens and ACTH but greater insulin resistance compared to those receiving hydrocortisone or prednisolone. Dexamethasone dose and once daily administration were associated with insulin resistance. Partial correlation analysis adjusted for age and sex showed PreDEq weakly correlated (r
    Original languageEnglish
    JournalClinical Endocrinology
    Publication statusPublished - 2012


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