Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase

Mark Pallen

Research output: Contribution to journalArticle

16 Citations (Scopus)


Phosphorylase kinase is a four-subunit enzyme involved in the regulation of glycogen breakdown. The traditional textbook view is that only the gamma subunit has enzymatic activity, whereas the other three subunits have a regulatory role. Evidence from homology searches and sequence alignments, however, shows that the alpha- and beta-subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase activity. If true, this would have important implications for the understanding, diagnosis, and management of glycogen storage diseases. There is thus a clear need to test this hypothesis through enzymatic assays and structural studies.
Original languageEnglish
Pages (from-to)1804-7
Number of pages4
JournalProtein Science
Issue number8
Publication statusPublished - 1 Aug 2003


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