Global genomic methylation levels in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus) after exposure to hexabromocyclododecane and 17-β oestradiol

Stanley Aniagu, Timothy Williams, Y Allen, I Katsiadaki, James Chipman

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)
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Abstract

Alteration of DNA methylation is a major epigenetic mechanism associated with the effects of nongenotoxic carcinogens. We evaluated the effects of two environmental pollutants, hexabromocyclododecane (HBCD), 17-beta oestradiol (E-2) as well as 5-aza 2' deoxycytidine (5AdC) on global DNA methylation levels (5-methyl 2' deoxycytidine) in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus). HBCD at 30 and 300 ng/L of water did not produce statistically significant differences in global genomic methylation in liver of female stickleback. On the other hand, the methylation inhibitor, 5-aza-2'-deoxycytidine, significantly lowered hepatic global methylation levels in these fish by 14% (P
Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalEnvironment International
Volume34
Issue number3
Early online date4 May 2007
DOIs
Publication statusPublished - Apr 2008

Keywords

  • hexabromocyclododecane
  • oestradiol
  • DNA methylation
  • stickleback

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