Global collaboration between platform trials in surgery and anaesthesia

James Glasbey; Steve A. Webb; Trisha Peel; Thomas D. Pinkney; Paul S. Myles

doi:10.1093/bjs/znae262

Global collaboration between platform trials in surgery and anaesthesia

James Glasbey^*, Steve A. Webb, Trisha Peel, Thomas D. Pinkney, Paul S. Myles^*

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

Original language	English
Article number	znae262
Number of pages	4
Journal	British Journal of Surgery
Volume	111
Issue number	12
Early online date	20 Dec 2024
DOIs	https://doi.org/10.1093/bjs/znae262
Publication status	Published - Dec 2024

Bibliographical note

This article was published jointly in the British Journal of Anaesthesia (BJA) and BJS reflecting the interdisciplinary nature of these research platforms.

© The Author(s) 2024 published by Oxford University Press on behalf of BJS Foundation Ltd and published by Elsevier Ltd on behalf of British Journal of Anaesthesia Society.

Keywords

adaptive trials
anaesthesia
colleborative research
perioperative care
platform trials
surgery
surgical site

Access to Document

10.1093/bjs/znae262Licence: Creative Commons: Attribution (CC BY)

GlasbeyJ2024GlobalFinal published version, 208 KBLicence: Creative Commons: Attribution (CC BY)

1 Comment/debate

Global collaboration between platform trials in surgery and anaesthesia
Glasbey, J., Webb, S. A., Peel, T., Pinkney, T. D. & Myles, P. S., Feb 2025, In: British Journal of Anaesthesia. 134, 2, p. 259-262 4 p.
Research output: Contribution to journal › Comment/debate › peer-review

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3 Active

NIHR163832 - ROSSINI-Platform - a 'Basket Factorial MAMS' Platform Trial in Surgical Site Infection
Monahan, M. (Researcher), Handley, K. (Researcher), Morris, K. (Researcher), Morton, V. (Researcher), Popplewell, M. (Researcher), Magill, L. (Co-Investigator), Pinkney, T. (Principal Investigator), Li, E. (Researcher), Oppong, R. (Co-Investigator) & Glasbey, J. (Researcher)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/01/25 → 31/12/29
Project: Other Government Departments
NIHR160509 - ROSSINI 2 EXTENSION - A Phase 3, multi-arm, multi-stage (MAMS), pragmatic, blinded multicentre RCT to evaluate the use of in-theatre interventions, alone or in combination, to reduce SSI rates in patients undergoing abdominal surgery
Magill, L. (Co-Investigator), Kaur, M. (Co-Investigator), Handley, K. (Co-Investigator) & Pinkney, T. (Principal Investigator)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/05/24 → 31/10/26
Project: Other Government Departments
16/31/123 - ROSSINI II Trial - Reduction Of Surgical Site Infection using several Novel Interventions. A multi-arm, multi-stage surgical RCT utilising an adaptive design - OPEN FOR DISSEMINATION ONLY
Magill, L. (Co-Investigator), Morton, D. (Co-Investigator), Handley, K. (Co-Investigator), Pinkney, T. (Principal Investigator) & Brocklehurst, P. (Co-Investigator)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/03/18 → 28/02/26
Project: Other Government Departments

Cite this

@article{b0139fe6fb0241368c77a58cf5e7e752,

title = "Global collaboration between platform trials in surgery and anaesthesia",

abstract = "Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.",

keywords = "adaptive trials, anaesthesia, colleborative research, perioperative care, platform trials, surgery, surgical site",

author = "James Glasbey and Webb, \{Steve A.\} and Trisha Peel and Pinkney, \{Thomas D.\} and Myles, \{Paul S.\}",

note = "This article was published jointly in the British Journal of Anaesthesia (BJA) and BJS reflecting the interdisciplinary nature of these research platforms. {\textcopyright} The Author(s) 2024 published by Oxford University Press on behalf of BJS Foundation Ltd and published by Elsevier Ltd on behalf of British Journal of Anaesthesia Society.",

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doi = "10.1093/bjs/znae262",

language = "English",

volume = "111",

journal = "British Journal of Surgery",

issn = "0007-1323",

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number = "12",

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AU - Glasbey, James

AU - Webb, Steve A.

AU - Peel, Trisha

AU - Pinkney, Thomas D.

AU - Myles, Paul S.

N1 - This article was published jointly in the British Journal of Anaesthesia (BJA) and BJS reflecting the interdisciplinary nature of these research platforms. © The Author(s) 2024 published by Oxford University Press on behalf of BJS Foundation Ltd and published by Elsevier Ltd on behalf of British Journal of Anaesthesia Society.

PY - 2024/12

Y1 - 2024/12

N2 - Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

AB - Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

KW - adaptive trials

KW - anaesthesia

KW - colleborative research

KW - perioperative care

KW - platform trials

KW - surgery

KW - surgical site

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U2 - 10.1093/bjs/znae262

DO - 10.1093/bjs/znae262

M3 - Comment/debate

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VL - 111

JO - British Journal of Surgery

JF - British Journal of Surgery

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M1 - znae262

ER -

Global collaboration between platform trials in surgery and anaesthesia

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Research output

Global collaboration between platform trials in surgery and anaesthesia

Projects

NIHR163832 - ROSSINI-Platform - a 'Basket Factorial MAMS' Platform Trial in Surgical Site Infection

NIHR160509 - ROSSINI 2 EXTENSION - A Phase 3, multi-arm, multi-stage (MAMS), pragmatic, blinded multicentre RCT to evaluate the use of in-theatre interventions, alone or in combination, to reduce SSI rates in patients undergoing abdominal surgery

16/31/123 - ROSSINI II Trial - Reduction Of Surgical Site Infection using several Novel Interventions. A multi-arm, multi-stage surgical RCT utilising an adaptive design - OPEN FOR DISSEMINATION ONLY

Cite this