GH receptor blocker administration and muscle-tendon collagen synthesis in humans

Rie H Nielsen, Simon Doessing, K. Goto, S Reitelseder, Lars Holm, J Agergaard, Peter Schjerling, A Flyvbjerg, Michael Kjær

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated. Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P 
Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalGrowth Hormone and IGF Research
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2011

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