GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients

Simon Doessing; Lars Holm; Katja Heinemeier; U.F. Rasmusen; P. Schjerling; K Qvortrup; Jytte Overgaard Larsen; Rie H Nielsen; A Flyvbjerg; Michael Kjær

doi:10.1530/EJE-10-0818

GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients

Simon Doessing, Lars Holm, Katja Heinemeier, U.F. Rasmusen, P. Schjerling, K Qvortrup, Jytte Overgaard Larsen, Rie H Nielsen, A Flyvbjerg, Michael Kjær

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

OBJECTIVE: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined.RESULTS AND CONCLUSIONS: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P

Original language	English
Pages (from-to)	853-862
Number of pages	10
Journal	European Journal of Endocrinology
Volume	163
Issue number	6
DOIs	https://doi.org/10.1530/EJE-10-0818
Publication status	Published - 1 Dec 2010

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Doessing, S., Holm, L., Heinemeier, K., Rasmusen, U. F., Schjerling, P., Qvortrup, K., Larsen, J. O., Nielsen, R. H., Flyvbjerg, A., & Kjær, M. (2010). GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients. European Journal of Endocrinology , 163(6), 853-862. https://doi.org/10.1530/EJE-10-0818

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title = "GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients",

abstract = "OBJECTIVE: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined.RESULTS AND CONCLUSIONS: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P",

author = "Simon Doessing and Lars Holm and Katja Heinemeier and U.F. Rasmusen and P. Schjerling and K Qvortrup and Larsen, {Jytte Overgaard} and Nielsen, {Rie H} and A Flyvbjerg and Michael Kj{\ae}r",

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Doessing, S, Holm, L, Heinemeier, K, Rasmusen, UF, Schjerling, P, Qvortrup, K, Larsen, JO, Nielsen, RH, Flyvbjerg, A & Kjær, M 2010, 'GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients', European Journal of Endocrinology , vol. 163, no. 6, pp. 853-862. https://doi.org/10.1530/EJE-10-0818

TY - JOUR

T1 - GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients

AU - Doessing, Simon

AU - Holm, Lars

AU - Heinemeier, Katja

AU - Rasmusen, U.F.

AU - Schjerling, P.

AU - Qvortrup, K

AU - Larsen, Jytte Overgaard

AU - Nielsen, Rie H

AU - Flyvbjerg, A

AU - Kjær, Michael

PY - 2010/12/1

Y1 - 2010/12/1

N2 - OBJECTIVE: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined.RESULTS AND CONCLUSIONS: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P

AB - OBJECTIVE: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined.RESULTS AND CONCLUSIONS: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P

U2 - 10.1530/EJE-10-0818

DO - 10.1530/EJE-10-0818

M3 - Article

SN - 0804-4643

VL - 163

SP - 853

EP - 862

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 6

ER -

GH and IGF-I levels are positively associated with musculotendinous collagen expression: Experiments in acromegalic and GHD patients

Abstract

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