Genomic imprinting syndromes and cancer.

Derek Lim; Eamonn Maher

doi:10.1016/B978-0-12-380866-0.60006-X

Genomic imprinting syndromes and cancer.

Derek Lim, Eamonn Maher

Birmingham Medical School

Research output: Contribution to journal › Review article

81 Citations (Scopus)

Abstract

Genomic imprinting represents a form of epigenetic control of gene expression in which one allele of a gene is preferentially expressed according to the parent-of-origin of the allele. Genomic imprinting plays an important role in normal growth and development. Disruption of imprinting can result in a number of human imprinting syndromes and predispose to cancer. In this chapter, we describe a number of human imprinting syndromes to illustrate the concepts of genomic imprinting and how loss of imprinting of imprinted genes their relationship to human neoplasia.

Original language	English
Pages (from-to)	145-75
Number of pages	31
Journal	Advances in Genetics
Volume	70
DOIs	https://doi.org/10.1016/B978-0-12-380866-0.60006-X
Publication status	Published - 1 Jan 2010

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10.1016/B978-0-12-380866-0.60006-X

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AB - Genomic imprinting represents a form of epigenetic control of gene expression in which one allele of a gene is preferentially expressed according to the parent-of-origin of the allele. Genomic imprinting plays an important role in normal growth and development. Disruption of imprinting can result in a number of human imprinting syndromes and predispose to cancer. In this chapter, we describe a number of human imprinting syndromes to illustrate the concepts of genomic imprinting and how loss of imprinting of imprinted genes their relationship to human neoplasia.

U2 - 10.1016/B978-0-12-380866-0.60006-X

DO - 10.1016/B978-0-12-380866-0.60006-X

M3 - Review article

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SP - 145

EP - 175

JO - Advances in Genetics

JF - Advances in Genetics

ER -

Genomic imprinting syndromes and cancer.

Abstract

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