Genomic imprinting of cancer, new paradigms in the genetics of neoplasia

PN Schofield, JA Joyce, WD Lam, V Grandjean, A Ferguson-Smith, W Reik, Eamonn Maher

    Research output: Contribution to journalLetter

    38 Citations (Scopus)


    The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.
    Original languageEnglish
    Pages (from-to)151-160
    Number of pages10
    JournalToxicology Letters
    Issue number1-3
    Publication statusPublished - 31 Mar 2001


    • methylation
    • CDKN1C
    • tumour suppressor gene
    • epimutation
    • chromosome 11
    • Beckwith-Wiedemann syndrome
    • Wilms' tumour
    • insulin-like growth factor-II
    • ageing
    • KCNQ1
    • imprinting
    • H19


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