Genomic imprinting of cancer, new paradigms in the genetics of neoplasia

PN Schofield; JA Joyce; WD Lam; V Grandjean; A Ferguson-Smith; W Reik; Eamonn Maher

doi:10.1016/S0378-4274(01)00294-6

Genomic imprinting of cancer, new paradigms in the genetics of neoplasia

PN Schofield, JA Joyce, WD Lam, V Grandjean, A Ferguson-Smith, W Reik, Eamonn Maher

Research output: Contribution to journal › Letter

38 Citations (Scopus)

Abstract

The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.

Original language	English
Pages (from-to)	151-160
Number of pages	10
Journal	Toxicology Letters
Volume	120
Issue number	1-3
DOIs	https://doi.org/10.1016/S0378-4274(01)00294-6
Publication status	Published - 31 Mar 2001

Keywords

methylation
CDKN1C
tumour suppressor gene
epimutation
chromosome 11
Beckwith-Wiedemann syndrome
Wilms' tumour
insulin-like growth factor-II
ageing
KCNQ1
imprinting
H19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0378-4274(01)00294-6

Cite this

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title = "Genomic imprinting of cancer, new paradigms in the genetics of neoplasia",

abstract = "The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.",

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AU - Schofield, PN

AU - Joyce, JA

AU - Lam, WD

AU - Grandjean, V

AU - Ferguson-Smith, A

AU - Reik, W

AU - Maher, Eamonn

PY - 2001/3/31

Y1 - 2001/3/31

N2 - The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.

AB - The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.

KW - methylation

KW - CDKN1C

KW - tumour suppressor gene

KW - epimutation

KW - chromosome 11

KW - Beckwith-Wiedemann syndrome

KW - Wilms' tumour

KW - insulin-like growth factor-II

KW - ageing

KW - KCNQ1

KW - imprinting

KW - H19

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DO - 10.1016/S0378-4274(01)00294-6

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SN - 1879-3169

VL - 120

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EP - 160

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1-3

ER -

Genomic imprinting of cancer, new paradigms in the genetics of neoplasia

Abstract

Keywords

UN SDGs

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