Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

I. Brænne; L. Zeng; C. Willenborg; V. Tragante; T. Kessler; C.J. Willer; M. Laakso; L. Wallentin; P.W. Franks; V. Salomaa; A. Dehghan; T. Meitinger; N.J. Samani; F.W. Asselbergs; J. Erdmann; H. Schunkert; P. Deloukas; S. Kanoni; M. Farrall; T.L. Assimes; J.R. Thompson; E. Ingelsson; D. Saleheen; B.A. Goldstein; D. Absher; I.R. König; K. Stirrups; Å. Johansson; A. Hall; J.-Y. Lee; J.C. Chambers; T. Esko; L. Folkersen; A. Goel; E. Grundberg; A.S. Havulinna; W.K. Ho; J.C. Hopewell; N. Eriksson; M.E. Kleber; K. Kristiansson; P. Lundmark; L.-P. Lyytikäinen; S. Rafelt; D. Shun; R.J. Strawbridge; G. Thorleifsson; E. Tikkanen; N. Van Zuydam; B.F. Voight; L.L. Waite; W. Zhang; A. Zieg; D. Altshuler; A.J. Balmforth; I. Barroso; P.S. Braund; C. Burgdorf; S. Claudi-Boehm; D. Cox; M. Dimitriou; R. Do; A.S.F. Doney; N.E. El Mokhtari; P. Eriksson; K. Fischer; P. Fontanillas; A. Franco-Cereceda; B. Gigante; L. Groop; S. Gustafsson; J. Hager; G. Hallmans; B.-G. Han; S. Ehunt; H.M. Kang; T. Illig; J.W. Knowles; G. Kolovou; J. Kuusisto; C. Langenberg; C. Langford; K. Leander; M.-L. Lokki; A. Lundmark; M.I. McCarthy; C. Meisinger; O. Melander; E. Mihailov; S. Maouche; A.D. Morris; M. Müller-Nurasyid; K. Nikus; J.F. Peden; N.W. Rayner; A. Rasheed; S. Rosinger; D. Rubin; M.P. Rumpf; A. Schäfer; M. Sivananthan; C. Song; A.F.R. Stewart; S.-T. Tan; G. Thorgeirsson; C.E. Van Der Schoot; P.J. Wagner; G.A. Wells; P.S. Wild; T.-P. Yang; P. Amouyel; D. Arveiler; H. Basart; M. Boehnke; E. Boerwinkle; P. Brambilla; F. Cambien; A.L. Cupples; U. De Faire; P. Diemert; S.E. Epstein; A. Evans; M.M. Ferrario; J. Ferrières; D. Gauguier; A.S. Go; A.H. Goodall; V. Gudnason; S.L. Hazen; H. Holm; C. Iribarren; Y. Jang; M. Kähönen; F. Kee; H.-S. Kim; N. Klopp; W. Koenig; W. Kratzer; K. Kuulasmaa; R. Laaksonen; J.-Y. Lee; L. Lind; W.H. Ouwehand; S. Parish; J.E. Park; N.L. Pedersen; A. Peters; T. Quertermous; D.J. Rader; E. Schadt; S.H. Shah; J. Sinisalo; K. Stark; K. Stefansson; D.-A. Trégouët; J. Virtamo; N. Wareham; M.E. Zimmermann; M.S. Nieminen; C. Hengsten; M.S. Sandhu; T. Pastinen; A.-C. Syvänen; G.K. Hovingh; G. Dedoussis; T. Lehtimäki; A. Metspalu; P.A. Zalloua; A. Siegbahn; S. Schreiber; S. Ripatti; S.S. Blankenberg; M. Perola; R. Clarke; B. Oboehm; C. O’Donnell; M.P. Reilly; W. März; R. Collins; S. Kathiresan; A. Hamsten; J.S. Kooner; U. Thorsteinsdottir; J. Danesh; C.N.A. Palmer; R. Roberts; H. Watkins; A. Hall; C. Hengstenberg; R. McPherson; A. Ziegler

doi:10.1371/journal.pone.0182999

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

I. Brænne, L. Zeng, C. Willenborg, V. Tragante, T. Kessler, C.J. Willer, M. Laakso, L. Wallentin, P.W. Franks, V. Salomaa, A. Dehghan, T. Meitinger, N.J. Samani, F.W. Asselbergs, J. Erdmann, H. Schunkert, P. Deloukas, S. Kanoni, M. Farrall, T.L. AssimesJ.R. Thompson, E. Ingelsson, D. Saleheen, B.A. Goldstein, D. Absher, I.R. König, K. Stirrups, Å. Johansson, A. Hall, J.-Y. Lee, J.C. Chambers, T. Esko, L. Folkersen, A. Goel, E. Grundberg, A.S. Havulinna, W.K. Ho, J.C. Hopewell, N. Eriksson, M.E. Kleber, K. Kristiansson, P. Lundmark, L.-P. Lyytikäinen, S. Rafelt, D. Shun, R.J. Strawbridge, G. Thorleifsson, E. Tikkanen, N. Van Zuydam, B.F. Voight, L.L. Waite, W. Zhang, A. Zieg, D. Altshuler, A.J. Balmforth, I. Barroso, P.S. Braund, C. Burgdorf, S. Claudi-Boehm, D. Cox, M. Dimitriou, R. Do, A.S.F. Doney, N.E. El Mokhtari, P. Eriksson, K. Fischer, P. Fontanillas, A. Franco-Cereceda, B. Gigante, L. Groop, S. Gustafsson, J. Hager, G. Hallmans, B.-G. Han, S. Ehunt, H.M. Kang, T. Illig, J.W. Knowles, G. Kolovou, J. Kuusisto, C. Langenberg, C. Langford, K. Leander, M.-L. Lokki, A. Lundmark, M.I. McCarthy, C. Meisinger, O. Melander, E. Mihailov, S. Maouche, A.D. Morris, M. Müller-Nurasyid, K. Nikus, J.F. Peden, N.W. Rayner, A. Rasheed, S. Rosinger, D. Rubin, M.P. Rumpf, A. Schäfer, M. Sivananthan, C. Song, A.F.R. Stewart, S.-T. Tan, G. Thorgeirsson, C.E. Van Der Schoot, P.J. Wagner, G.A. Wells, P.S. Wild, T.-P. Yang, P. Amouyel, D. Arveiler, H. Basart, M. Boehnke, E. Boerwinkle, P. Brambilla, F. Cambien, A.L. Cupples, U. De Faire, P. Diemert, S.E. Epstein, A. Evans, M.M. Ferrario, J. Ferrières, D. Gauguier, A.S. Go, A.H. Goodall, V. Gudnason, S.L. Hazen, H. Holm, C. Iribarren, Y. Jang, M. Kähönen, F. Kee, H.-S. Kim, N. Klopp, W. Koenig, W. Kratzer, K. Kuulasmaa, R. Laaksonen, J.-Y. Lee, L. Lind, W.H. Ouwehand, S. Parish, J.E. Park, N.L. Pedersen, A. Peters, T. Quertermous, D.J. Rader, E. Schadt, S.H. Shah, J. Sinisalo, K. Stark, K. Stefansson, D.-A. Trégouët, J. Virtamo, N. Wareham, M.E. Zimmermann, M.S. Nieminen, C. Hengsten, M.S. Sandhu, T. Pastinen, A.-C. Syvänen, G.K. Hovingh, G. Dedoussis, T. Lehtimäki, A. Metspalu, P.A. Zalloua, A. Siegbahn, S. Schreiber, S. Ripatti, S.S. Blankenberg, M. Perola, R. Clarke, B. Oboehm, C. O’Donnell, M.P. Reilly, W. März, R. Collins, S. Kathiresan, A. Hamsten, J.S. Kooner, U. Thorsteinsdottir, J. Danesh, C.N.A. Palmer, R. Roberts, H. Watkins, A. Hall, C. Hengstenberg, R. McPherson, A. Ziegler

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	PLOS One
DOIs	https://doi.org/10.1371/journal.pone.0182999
Publication status	Published - 2017

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10.1371/journal.pone.0182999

Cite this

Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., Willer, C. J., Laakso, M., Wallentin, L., Franks, P. W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N. J., Asselbergs, F. W., Erdmann, J., Schunkert, H., Deloukas, P., Kanoni, S., Farrall, M., ... Ziegler, A. (2017). Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLOS One. https://doi.org/10.1371/journal.pone.0182999

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title = "Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk",

author = "I. Br{\ae}nne and L. Zeng and C. Willenborg and V. Tragante and T. Kessler and C.J. Willer and M. Laakso and L. Wallentin and P.W. Franks and V. Salomaa and A. Dehghan and T. Meitinger and N.J. Samani and F.W. Asselbergs and J. Erdmann and H. Schunkert and P. Deloukas and S. Kanoni and M. Farrall and T.L. Assimes and J.R. Thompson and E. Ingelsson and D. Saleheen and B.A. Goldstein and D. Absher and I.R. K{\"o}nig and K. Stirrups and {\AA}. Johansson and A. Hall and J.-Y. Lee and J.C. Chambers and T. Esko and L. Folkersen and A. Goel and E. Grundberg and A.S. Havulinna and W.K. Ho and J.C. Hopewell and N. Eriksson and M.E. Kleber and K. Kristiansson and P. Lundmark and L.-P. Lyytik{\"a}inen and S. Rafelt and D. Shun and R.J. Strawbridge and G. Thorleifsson and E. Tikkanen and {Van Zuydam}, N. and B.F. Voight and L.L. Waite and W. Zhang and A. Zieg and D. Altshuler and A.J. Balmforth and I. Barroso and P.S. Braund and C. Burgdorf and S. Claudi-Boehm and D. Cox and M. Dimitriou and R. Do and A.S.F. Doney and {El Mokhtari}, N.E. and P. Eriksson and K. Fischer and P. Fontanillas and A. Franco-Cereceda and B. Gigante and L. Groop and S. Gustafsson and J. Hager and G. Hallmans and B.-G. Han and S. Ehunt and H.M. Kang and T. Illig and J.W. Knowles and G. Kolovou and J. Kuusisto and C. Langenberg and C. Langford and K. Leander and M.-L. Lokki and A. Lundmark and M.I. McCarthy and C. Meisinger and O. Melander and E. Mihailov and S. Maouche and A.D. Morris and M. M{\"u}ller-Nurasyid and K. Nikus and J.F. Peden and N.W. Rayner and A. Rasheed and S. Rosinger and D. Rubin and M.P. Rumpf and A. Sch{\"a}fer and M. Sivananthan and C. Song and A.F.R. Stewart and S.-T. Tan and G. Thorgeirsson and {Van Der Schoot}, C.E. and P.J. Wagner and G.A. Wells and P.S. Wild and T.-P. Yang and P. Amouyel and D. Arveiler and H. Basart and M. Boehnke and E. Boerwinkle and P. Brambilla and F. Cambien and A.L. Cupples and {De Faire}, U. and P. Diemert and S.E. Epstein and A. Evans and M.M. Ferrario and J. Ferri{\`e}res and D. Gauguier and A.S. Go and A.H. Goodall and V. Gudnason and S.L. Hazen and H. Holm and C. Iribarren and Y. Jang and M. K{\"a}h{\"o}nen and F. Kee and H.-S. Kim and N. Klopp and W. Koenig and W. Kratzer and K. Kuulasmaa and R. Laaksonen and J.-Y. Lee and L. Lind and W.H. Ouwehand and S. Parish and J.E. Park and N.L. Pedersen and A. Peters and T. Quertermous and D.J. Rader and E. Schadt and S.H. Shah and J. Sinisalo and K. Stark and K. Stefansson and D.-A. Tr{\'e}gou{\"e}t and J. Virtamo and N. Wareham and M.E. Zimmermann and M.S. Nieminen and C. Hengsten and M.S. Sandhu and T. Pastinen and A.-C. Syv{\"a}nen and G.K. Hovingh and G. Dedoussis and T. Lehtim{\"a}ki and A. Metspalu and P.A. Zalloua and A. Siegbahn and S. Schreiber and S. Ripatti and S.S. Blankenberg and M. Perola and R. Clarke and B. Oboehm and C. O{\textquoteright}Donnell and M.P. Reilly and W. M{\"a}rz and R. Collins and S. Kathiresan and A. Hamsten and J.S. Kooner and U. Thorsteinsdottir and J. Danesh and C.N.A. Palmer and R. Roberts and H. Watkins and A. Hall and C. Hengstenberg and R. McPherson and A. Ziegler",

year = "2017",

doi = "10.1371/journal.pone.0182999",

language = "English",

journal = "PLOS One",

issn = "1932-6203",

publisher = "Public Library of Science (PLOS)",

}

Brænne, I, Zeng, L, Willenborg, C, Tragante, V, Kessler, T, Willer, CJ, Laakso, M, Wallentin, L, Franks, PW, Salomaa, V, Dehghan, A, Meitinger, T, Samani, NJ, Asselbergs, FW, Erdmann, J, Schunkert, H, Deloukas, P, Kanoni, S, Farrall, M, Assimes, TL, Thompson, JR, Ingelsson, E, Saleheen, D, Goldstein, BA, Absher, D, König, IR, Stirrups, K, Johansson, Å, Hall, A, Lee, J-Y, Chambers, JC, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, AS, Ho, WK, Hopewell, JC, Eriksson, N, Kleber, ME, Kristiansson, K, Lundmark, P, Lyytikäinen, L-P, Rafelt, S, Shun, D, Strawbridge, RJ, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, BF, Waite, LL, Zhang, W, Zieg, A, Altshuler, D, Balmforth, AJ, Barroso, I, Braund, PS, Burgdorf, C, Claudi-Boehm, S, Cox, D, Dimitriou, M, Do, R, Doney, ASF, El Mokhtari, NE, Eriksson, P, Fischer, K, Fontanillas, P, Franco-Cereceda, A, Gigante, B, Groop, L, Gustafsson, S, Hager, J, Hallmans, G, Han, B-G, Ehunt, S, Kang, HM, Illig, T, Knowles, JW, Kolovou, G, Kuusisto, J, Langenberg, C, Langford, C, Leander, K, Lokki, M-L, Lundmark, A, McCarthy, MI, Meisinger, C, Melander, O, Mihailov, E, Maouche, S, Morris, AD, Müller-Nurasyid, M, Nikus, K, Peden, JF, Rayner, NW, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, MP, Schäfer, A, Sivananthan, M, Song, C, Stewart, AFR, Tan, S-T, Thorgeirsson, G, Van Der Schoot, CE, Wagner, PJ, Wells, GA, Wild, PS, Yang, T-P, Amouyel, P, Arveiler, D, Basart, H, Boehnke, M, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, AL, De Faire, U, Diemert, P, Epstein, SE, Evans, A, Ferrario, MM, Ferrières, J, Gauguier, D, Go, AS, Goodall, AH, Gudnason, V, Hazen, SL, Holm, H, Iribarren, C, Jang, Y, Kähönen, M, Kee, F, Kim, H-S, Klopp, N, Koenig, W, Kratzer, W, Kuulasmaa, K, Laaksonen, R, Lee, J-Y, Lind, L, Ouwehand, WH, Parish, S, Park, JE, Pedersen, NL, Peters, A, Quertermous, T, Rader, DJ, Schadt, E, Shah, SH, Sinisalo, J, Stark, K, Stefansson, K, Trégouët, D-A, Virtamo, J, Wareham, N, Zimmermann, ME, Nieminen, MS, Hengsten, C, Sandhu, MS, Pastinen, T, Syvänen, A-C, Hovingh, GK, Dedoussis, G, Lehtimäki, T, Metspalu, A, Zalloua, PA, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, SS, Perola, M, Clarke, R, Oboehm, B, O’Donnell, C, Reilly, MP, März, W, Collins, R, Kathiresan, S, Hamsten, A, Kooner, JS, Thorsteinsdottir, U, Danesh, J, Palmer, CNA, Roberts, R, Watkins, H, Hall, A, Hengstenberg, C, McPherson, R & Ziegler, A 2017, 'Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk', PLOS One. https://doi.org/10.1371/journal.pone.0182999

TY - JOUR

T1 - Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

AU - Brænne, I.

AU - Zeng, L.

AU - Willenborg, C.

AU - Tragante, V.

AU - Kessler, T.

AU - Willer, C.J.

AU - Laakso, M.

AU - Wallentin, L.

AU - Franks, P.W.

AU - Salomaa, V.

AU - Dehghan, A.

AU - Meitinger, T.

AU - Samani, N.J.

AU - Asselbergs, F.W.

AU - Erdmann, J.

AU - Schunkert, H.

AU - Deloukas, P.

AU - Kanoni, S.

AU - Farrall, M.

AU - Assimes, T.L.

AU - Thompson, J.R.

AU - Ingelsson, E.

AU - Saleheen, D.

AU - Goldstein, B.A.

AU - Absher, D.

AU - König, I.R.

AU - Stirrups, K.

AU - Johansson, Å.

AU - Hall, A.

AU - Lee, J.-Y.

AU - Chambers, J.C.

AU - Esko, T.

AU - Folkersen, L.

AU - Goel, A.

AU - Grundberg, E.

AU - Havulinna, A.S.

AU - Ho, W.K.

AU - Hopewell, J.C.

AU - Eriksson, N.

AU - Kleber, M.E.

AU - Kristiansson, K.

AU - Lundmark, P.

AU - Lyytikäinen, L.-P.

AU - Rafelt, S.

AU - Shun, D.

AU - Strawbridge, R.J.

AU - Thorleifsson, G.

AU - Tikkanen, E.

AU - Van Zuydam, N.

AU - Voight, B.F.

AU - Waite, L.L.

AU - Zhang, W.

AU - Zieg, A.

AU - Altshuler, D.

AU - Balmforth, A.J.

AU - Barroso, I.

AU - Braund, P.S.

AU - Burgdorf, C.

AU - Claudi-Boehm, S.

AU - Cox, D.

AU - Dimitriou, M.

AU - Do, R.

AU - Doney, A.S.F.

AU - El Mokhtari, N.E.

AU - Eriksson, P.

AU - Fischer, K.

AU - Fontanillas, P.

AU - Franco-Cereceda, A.

AU - Gigante, B.

AU - Groop, L.

AU - Gustafsson, S.

AU - Hager, J.

AU - Hallmans, G.

AU - Han, B.-G.

AU - Ehunt, S.

AU - Kang, H.M.

AU - Illig, T.

AU - Knowles, J.W.

AU - Kolovou, G.

AU - Kuusisto, J.

AU - Langenberg, C.

AU - Langford, C.

AU - Leander, K.

AU - Lokki, M.-L.

AU - Lundmark, A.

AU - McCarthy, M.I.

AU - Meisinger, C.

AU - Melander, O.

AU - Mihailov, E.

AU - Maouche, S.

AU - Morris, A.D.

AU - Müller-Nurasyid, M.

AU - Nikus, K.

AU - Peden, J.F.

AU - Rayner, N.W.

AU - Rasheed, A.

AU - Rosinger, S.

AU - Rubin, D.

AU - Rumpf, M.P.

AU - Schäfer, A.

AU - Sivananthan, M.

AU - Song, C.

AU - Stewart, A.F.R.

AU - Tan, S.-T.

AU - Thorgeirsson, G.

AU - Van Der Schoot, C.E.

AU - Wagner, P.J.

AU - Wells, G.A.

AU - Wild, P.S.

AU - Yang, T.-P.

AU - Amouyel, P.

AU - Arveiler, D.

AU - Basart, H.

AU - Boehnke, M.

AU - Boerwinkle, E.

AU - Brambilla, P.

AU - Cambien, F.

AU - Cupples, A.L.

AU - De Faire, U.

AU - Diemert, P.

AU - Epstein, S.E.

AU - Evans, A.

AU - Ferrario, M.M.

AU - Ferrières, J.

AU - Gauguier, D.

AU - Go, A.S.

AU - Goodall, A.H.

AU - Gudnason, V.

AU - Hazen, S.L.

AU - Holm, H.

AU - Iribarren, C.

AU - Jang, Y.

AU - Kähönen, M.

AU - Kee, F.

AU - Kim, H.-S.

AU - Klopp, N.

AU - Koenig, W.

AU - Kratzer, W.

AU - Kuulasmaa, K.

AU - Laaksonen, R.

AU - Lee, J.-Y.

AU - Lind, L.

AU - Ouwehand, W.H.

AU - Parish, S.

AU - Park, J.E.

AU - Pedersen, N.L.

AU - Peters, A.

AU - Quertermous, T.

AU - Rader, D.J.

AU - Schadt, E.

AU - Shah, S.H.

AU - Sinisalo, J.

AU - Stark, K.

AU - Stefansson, K.

AU - Trégouët, D.-A.

AU - Virtamo, J.

AU - Wareham, N.

AU - Zimmermann, M.E.

AU - Nieminen, M.S.

AU - Hengsten, C.

AU - Sandhu, M.S.

AU - Pastinen, T.

AU - Syvänen, A.-C.

AU - Hovingh, G.K.

AU - Dedoussis, G.

AU - Lehtimäki, T.

AU - Metspalu, A.

AU - Zalloua, P.A.

AU - Siegbahn, A.

AU - Schreiber, S.

AU - Ripatti, S.

AU - Blankenberg, S.S.

AU - Perola, M.

AU - Clarke, R.

AU - Oboehm, B.

AU - O’Donnell, C.

AU - Reilly, M.P.

AU - März, W.

AU - Collins, R.

AU - Kathiresan, S.

AU - Hamsten, A.

AU - Kooner, J.S.

AU - Thorsteinsdottir, U.

AU - Danesh, J.

AU - Palmer, C.N.A.

AU - Roberts, R.

AU - Watkins, H.

AU - Hall, A.

AU - Hengstenberg, C.

AU - McPherson, R.

AU - Ziegler, A.

PY - 2017

Y1 - 2017

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85028551507&partnerID=MN8TOARS

U2 - 10.1371/journal.pone.0182999

DO - 10.1371/journal.pone.0182999

M3 - Article

SN - 1932-6203

JO - PLOS One

JF - PLOS One

ER -