Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression

A Schosser; AW Butler; M Ising; N Perroud; R Uher; MY Ng; S Cohen-Woods; N Craddock; MJ Owen; A Korszun; Lisa Jones; I Jones; M Gill; JP Rice; W Maier; O Mors; M Rietschel; S Lucae; EB Binder; M Preisig; J Perry; F Tozzi; P Muglia; KJ Aitchison; G Breen; IW Craig; AE Farmer; B Mueller-Myhsok; P McGuffin; CM Lewis

doi:10.1371/journal.pone.0020690

Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression

A Schosser, AW Butler, M Ising, N Perroud, R Uher, MY Ng, S Cohen-Woods, N Craddock, MJ Owen, A Korszun, Lisa Jones, I Jones, M Gill, JP Rice, W Maier, O Mors, M Rietschel, S Lucae, EB Binder, M PreisigJ Perry, F Tozzi, P Muglia, KJ Aitchison, G Breen, IW Craig, AE Farmer, B Mueller-Myhsok, P McGuffin, CM Lewis

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Abstract

Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. Methodology/Principal Findings: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of

Original language	English
Article number	e20690
Pages (from-to)	e20690
Journal	PLoS ONE
Volume	6
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0020690
Publication status	Published - 1 Jul 2011

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10.1371/journal.pone.0020690

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Schosser, A., Butler, AW., Ising, M., Perroud, N., Uher, R., Ng, MY., Cohen-Woods, S., Craddock, N., Owen, MJ., Korszun, A., Jones, L., Jones, I., Gill, M., Rice, JP., Maier, W., Mors, O., Rietschel, M., Lucae, S., Binder, EB., ... Lewis, CM. (2011). Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression. PLoS ONE, 6(7), e20690. Article e20690. https://doi.org/10.1371/journal.pone.0020690

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abstract = "Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. Methodology/Principal Findings: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of ",

author = "A Schosser and AW Butler and M Ising and N Perroud and R Uher and MY Ng and S Cohen-Woods and N Craddock and MJ Owen and A Korszun and Lisa Jones and I Jones and M Gill and JP Rice and W Maier and O Mors and M Rietschel and S Lucae and EB Binder and M Preisig and J Perry and F Tozzi and P Muglia and KJ Aitchison and G Breen and IW Craig and AE Farmer and B Mueller-Myhsok and P McGuffin and CM Lewis",

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Schosser, A, Butler, AW, Ising, M, Perroud, N, Uher, R, Ng, MY, Cohen-Woods, S, Craddock, N, Owen, MJ, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, JP, Maier, W, Mors, O, Rietschel, M, Lucae, S, Binder, EB, Preisig, M, Perry, J, Tozzi, F, Muglia, P, Aitchison, KJ, Breen, G, Craig, IW, Farmer, AE, Mueller-Myhsok, B, McGuffin, P & Lewis, CM 2011, 'Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression', PLoS ONE, vol. 6, no. 7, e20690, pp. e20690. https://doi.org/10.1371/journal.pone.0020690

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AU - Schosser, A

AU - Butler, AW

AU - Ising, M

AU - Perroud, N

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AU - Ng, MY

AU - Cohen-Woods, S

AU - Craddock, N

AU - Owen, MJ

AU - Korszun, A

AU - Jones, Lisa

AU - Jones, I

AU - Gill, M

AU - Rice, JP

AU - Maier, W

AU - Mors, O

AU - Rietschel, M

AU - Lucae, S

AU - Binder, EB

AU - Preisig, M

AU - Perry, J

AU - Tozzi, F

AU - Muglia, P

AU - Aitchison, KJ

AU - Breen, G

AU - Craig, IW

AU - Farmer, AE

AU - Mueller-Myhsok, B

AU - McGuffin, P

AU - Lewis, CM

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N2 - Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. Methodology/Principal Findings: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of

AB - Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. Methodology/Principal Findings: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of

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DO - 10.1371/journal.pone.0020690

M3 - Article

C2 - 21750702

SN - 1932-6203

VL - 6

SP - e20690

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e20690

ER -

Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression

Abstract

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