Genome-wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes

ML Hamshere, NM Williams, N Norton, H Williams, AG Cardno, S Zammit, Lisa Jones, KC Murphy, RD Sanders, G McCarthy, MY Gray, G Jones, P Holmans, MC O'Donovan, MJ Owen, N Craddock

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    BACKGROUND: Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression. METHODS: We undertook analyses in an attempt to detect loci that influence susceptibility to, or modify the clinical expression of, schizophrenia according to the occurrence of episodes of major depression. We used a logistic regression framework in which lifetime presence/absence of major depression was entered as a covariate in the linkage analysis of our UK schizophrenia affected sibling pair series (168 affected sibling pairs typed for a 10 cM map of microsatellite markers). RESULTS: Inclusion of presence/absence of depression as a covariate detected a genome wide significant linkage signal on chromosome 4q28.3 at 130.7 cM (LOD = 4.59; p = 0.038; increase in maximum LOD over univariate analysis (ILOD) = 3.62). Inclusion of the depression covariate also showed suggestive evidence of linkage on 20q11.21 (LOD = 4.10; expected to occur by chance 0.093 times per genome scan, ILOD = 2.83). CONCLUSIONS: Our findings identify loci that may harbour genes that play a role in susceptibility to, or modify the risk of, episodes of major depression in people with schizophrenia.
    Original languageEnglish
    Pages (from-to)563-567
    Number of pages5
    JournalJournal of Medical Genetics
    Volume43
    DOIs
    Publication statusPublished - 18 Nov 2005

    Fingerprint

    Dive into the research topics of 'Genome-wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes'. Together they form a unique fingerprint.

    Cite this