TY - JOUR
T1 - Genome-wide signatures of male-mediated migration shaping the Indian gene pool
AU - The Genographic Consortium
AU - Arunkumar, Ganeshprasad
AU - Tatarinova, Tatiana V.
AU - Duty, Jeff
AU - Rollo, Debra
AU - Syama, Adhikarla
AU - Arun, Varatharajan Santhakumari
AU - Kavitha, Valampuri John
AU - Triska, Petr
AU - Greenspan, Bennett
AU - Wells, R. Spencer
AU - Pitchappan, Ramasamy
AU - Adlera, Christina J.
AU - Balanovska, Elena
AU - Balanovsky, Oleg
AU - Bertranpetit, Jaume
AU - Clarke, Andrew C.
AU - Comas, David
AU - Cooper, Alan
AU - Der Sarkissian, Clio S.I.
AU - Dulik, Matthew C.
AU - Gaieski, Jill B.
AU - Haak, Wolfgang
AU - Haber, Marc
AU - Hobbs, Angela
AU - Javed, Asif
AU - Jin, Li
AU - Kaplan, Matthew E.
AU - Li, Shilin
AU - Martínez-Cruz, Begoña
AU - Matisoo-Smith, Elizabeth A.
AU - Melé, Marta
AU - Merchant, Nirav C.
AU - Mitchell, R. John
AU - Owings, Amanda C.
AU - Parida, Laxmi
AU - Platt, Daniel E.
AU - Quintana-Murci, Lluis
AU - Renfrew, Colin
AU - Lacerda, Daniela R.
AU - Royyuru, Ajay K.
AU - Schurr, Theodore G.
AU - Santos, Fabrício R.
AU - Soodyall, Himla
AU - Hernanz, David F.Soria
AU - Swamikrishnan, Pandikumar
AU - Tyler-Smith, Chris
AU - Vieira, Pedro Paulo
AU - Vilar, Miguel G.
AU - Zalloua, Pierre A.
AU - Ziegle, Janet S.
N1 - Publisher Copyright:
© 2015 The Japan Society of Human Genetics.
PY - 2015/9/29
Y1 - 2015/9/29
N2 - Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F∗-M89, H∗-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.
AB - Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F∗-M89, H∗-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.
UR - http://www.scopus.com/inward/record.url?scp=84942788454&partnerID=8YFLogxK
U2 - 10.1038/jhg.2015.51
DO - 10.1038/jhg.2015.51
M3 - Article
C2 - 25994871
AN - SCOPUS:84942788454
SN - 1434-5161
VL - 60
SP - 493
EP - 499
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 9
ER -