TY - JOUR
T1 - Genetics of Parkinsonism
AU - Lewthwaite, Alistair
AU - Nicholl, David
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Some debate still exists as to whether PD is predominantly environmental or genetic in etiology. The genetic hypothesis of PD etiology has been driven recently by the identification of a number of PD loci. This review deals with each of these loci, discussing the latest data and evidence available. Of particular interest are the recently described mutations in the PINK1 (PARK6) and LRRK2 (PARK8) genes. We also consider the impact of these latest developments on our understanding of sporadic PD and on our everyday practice with PD patients.
AB - Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Some debate still exists as to whether PD is predominantly environmental or genetic in etiology. The genetic hypothesis of PD etiology has been driven recently by the identification of a number of PD loci. This review deals with each of these loci, discussing the latest data and evidence available. Of particular interest are the recently described mutations in the PINK1 (PARK6) and LRRK2 (PARK8) genes. We also consider the impact of these latest developments on our understanding of sporadic PD and on our everyday practice with PD patients.
UR - http://www.scopus.com/inward/record.url?scp=84860214833&partnerID=8YFLogxK
U2 - 10.1007/s11910-005-0064-6
DO - 10.1007/s11910-005-0064-6
M3 - Review article
C2 - 16131423
SN - 1534-6293
VL - 5
SP - 397
EP - 404
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
IS - 5
ER -